O-DMTr-lithocholic alcohol | 849737-91-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: O-DMTr-lithocholic alcohol
• CAS: 849737-91-3
• 化学式: C₄₅H₆₀O₄
• 分子量: 664.969
• InChiKey: HXXPETJMKGPPEJ-MOYWJSAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.45
• 重原子数：
  49.0
• 可旋转键数：
  11.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  O-DMTr-lithocholic alcohol 在 N-甲基咪唑 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Structure-Activity Relationships of Cytotoxic Cholesterol-Modified DNA Duplexes

  摘要：

  Short DNA duplexes with cholesterol linked at the 3'-terminus of each strand have unique, selective cytotoxic properties. The structural requirements for biological activity were explored through chemical synthesis of analogs and testing in cultured hepatoma cells. Effects of modifications to the sequence, backbone, 3'-sterol, 3'-linker, and 5'-terminus were evaluated. Self-complementary 3'-modified oligodeoxynucleotide (ODN) 10-mers were prepared from solid supports bearing the modification and linker of interest. Any changes to the normal phosphodiester backbone were poorly tolerated. The presence of cholesterol or a closely related sterol was an absolute requirement for activity. The length and position of attachment of the linker to cholesterol was important, with longer linkers showing reduced activity. Large, lipophilic groups at the 5'-terminus gave reduced cytotoxicity and poor solubility properties. The short length and unique structure of these ODNs allowed efficient automated synthesis on a 400 mu mol scale and simplified purification.

  DOI：

  10.1021/jm00022a025
• 作为产物：
  描述：

  石胆酸 在 吡啶 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 硫酸 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 生成 O-DMTr-lithocholic alcohol
  参考文献：
  名称：

  食品毒素白霉素的合成受体的开发：咔唑和类固醇的故事。

  摘要：

  描述了对毒性离子载体环二肽肽金紫霉素具有高亲和力的第一合成受体的合成。结合导致受体的荧光强度显着增加，而对于非常相似的离子载体（如缬氨霉素）则未观察到这种增加。讨论了揭示这种选择性性质的实验。

  DOI：

  10.1021/acs.orglett.8b02630

文献信息

• [EN] SYNTHETIC RECEPTORS FOR IONOPHORIC COMPOUNDS<br/>[FR] RÉCEPTEURS SYNTHÉTIQUES POUR COMPOSÉS IONOPHORES
  申请人：UNIV GENT

  公开号：WO2019166475A1

  公开（公告）日：2019-09-06

  The present invention relates to synthetic receptors for ionophoric compounds, such as ionophoric toxins. Hence, the invention provides synthetic molecules capable of binding different ionophoric compounds, thereby being suitable for use in the detection, isolation and detoxification of such ionophoric compounds. The present invention further provides the use of such synthetic receptors in human and veterinary medicine, such as in the diagnosis, prevention and/or treatment of disorders caused by such ionophoric compounds. Finally, the invention provides methods of preparing such synthetic receptors for ionophoric compounds.

  本发明涉及用于离子载体化合物的合成受体，例如离子载体毒素。因此，本发明提供了能够结合不同离子载体化合物的合成分子，从而适用于检测、分离和解毒此类离子载体化合物。本发明还提供了在人类和兽医学中使用这种合成受体的方法，例如在诊断、预防和/或治疗由这类离子载体化合物引起的疾病。最后，本发明提供了制备此类离子载体化合物的合成受体的方法。
• [EN] NEW PHOSPHORAMIDITE COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES PHOSPHORAMIDITES
  申请人：POSTECH FOUNDATION

  公开号：WO2004063208A1

  公开（公告）日：2004-07-29

  Novel phosphoramidites having various functional groups can be advantageously used as new building blocks to synthesize various oligodeoxyribonucleotides which are useful for the development of a highly efficient diagnostic agent and the synthesis of new nano structural oligodeoxyribonucleotides.

  具有各种功能基团的新型磷酰胺酯可以优势地用作合成各种寡脱氧核苷酸的新建筑单元，这对于开发高效的诊断试剂和合成新的纳米结构寡脱氧核苷酸是有用的。