4-(2-fluoropyridin-4-yl)-9-(4-methoxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-one | 916345-34-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(2-fluoropyridin-4-yl)-9-(4-methoxyphenyl)-1-oxa-4,9-diazaspiro[5,5]undecan-3-one
• 英文别名: 4-(2-Fluoropyridin-4-yl)-9-(4-methoxyphenyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
• CAS: 916345-34-1
• 化学式: C₂₀H₂₂FN₃O₃
• 分子量: 371.411
• InChiKey: KJZKKUAPQAWWID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Novel Piperidine Derivative
  申请人：Ishikawa Shiho

  公开号：US20090137576A1

  公开（公告）日：2009-05-28

  Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein R1 represents a phenyl group which may be substituted or the like and R2 represents a cyano group which may be substituted or the like, or R1 and R2 together form an aliphatic heterocylic ring which may be substituted; R3 represents a group represented by the formula (II-1) below; and all of X1 to X4 represent a carbon atom or the like: (II-1) where R4 and R5 represent a lower alkyl group or the like; and m1 represents an integer of 2 to 4.

  本发明涉及一种物质，其对组胺与组胺H3受体的结合具有拮抗作用，或对组胺H3受体不断表现的活性具有抑制作用。化合物由式(I)或其药学上可接受的盐表示；(I)其中R1代表可能被取代或类似的苯基团，R2代表可能被取代或类似的氰基团，或R1和R2一起形成可能被取代的脂肪族杂环环；R3代表由下式(II-1)表示的基团；X1到X4都表示碳原子或类似物：(II-1)其中R4和R5代表较低的烷基团或类似物；m1表示2到4的整数。
• NOVEL PIPERIDINE DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP1892241A1

  公开（公告）日：2008-02-27

  Disclosed is a substance having an antagonistic effect on the binding of histamine to a histamine H3 receptor or an inhibitory effect on the activity which a histamine H3 receptor constantly exhibits. A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof; (I) wherein R1 represents a phenyl group which may be substituted or the like and R2 represents a cyano group which may be substituted or the like, or R1 and R2 together form an aliphatic heterocylic ring which may be substituted; R3 represents a group represented by the formula (II-1) below; and all of X1 to X4 represent a carbon atom or the like: (II-1) where R4 and R5 represent a lower alkyl group or the like; and ml represents an integer of 2 to 4.

  本发明公开了一种对组胺与组胺 H3 受体的结合具有拮抗作用或对组胺 H3 受体持续表现出的活性具有抑制作用的物质。由式(I)代表的化合物或其药学上可接受的盐； (I) 其中 R1 代表可被取代的苯基或类似基团，R2 代表可被取代的氰基或类似基团，或 R1 和 R2 共同形成可被取代的脂族杂环；R3 代表下式(II-1)所代表的基团； 且所有 X1 至 X4 均代表碳原子或类似物：(II-1) 其中 R4 和 R5 代表低级烷基或类似基团；ml 代表 2 至 4 的整数。
• US8138206B2
  申请人：——

  公开号：US8138206B2

  公开（公告）日：2012-03-20