5-(4-bromobenzyl)-6-butyl-2-cyclopropyl-3-(5-methoxypyrimidin-2-yl)pyrimidin-4(3H)-one | 1268156-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-(4-bromobenzyl)-6-butyl-2-cyclopropyl-3-(5-methoxypyrimidin-2-yl)pyrimidin-4(3H)-one
• 英文别名: 5-[(4-Bromophenyl)methyl]-6-butyl-2-cyclopropyl-3-(5-methoxypyrimidin-2-yl)pyrimidin-4-one
• CAS: 1268156-00-8
• 化学式: C₂₃H₂₅BrN₄O₂
• 分子量: 469.381
• InChiKey: TWXPMXDZDDMFLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
  申请人：Miura Toru

  公开号：US20120122906A1

  公开（公告）日：2012-05-17

  Disclosed is a novel compound which has both angiotensin II receptor antagonist activity and PPARγ activating activity, and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, kidney diseases, arteriosclerosis, inflammatory diseases, type 2 diabetes, diabetic complication, insulin resistant syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. Also disclosed is a pharmaceutical composition which contains the novel compound. Specifically disclosed are: a sulfonamide derivative represented by general formula (I), a salt thereof, or a solvate of the derivative or salt; and a pharmaceutical composition which contains the sulfonamide derivative, a salt thereof, or a solvate of the derivative or salt. (In the formula, R 1 represents a C 1-6 alkyl group; R 2 and R 3 each represents a C 1-6 alkyl group or the like; and R 4 represents a hydrogen atom, a C 1-6 alkyl group, a C 1-6 alkanoyl group or a C 3-8 cycloalkylcarbonyl group.)

  本发明揭示了一种新型化合物，具有血管紧张素II受体拮抗活性和PPARγ激活活性，可用作高血压、心脏疾病、心绞痛、脑血管疾病、脑循环障碍、缺血性外周循环障碍、肾脏疾病、动脉硬化、炎症性疾病、2型糖尿病、糖尿病并发症、胰岛素抵抗综合征、X综合征、代谢综合征和高胰岛素血症的预防和/或治疗剂。还揭示了一种含有该新型化合物的药物组合物。具体揭示了：一种由通式（I）表示的磺胺衍生物，其盐或该衍生物或盐的溶剂；以及含有该磺胺衍生物、其盐或该衍生物或盐的溶剂的药物组合物。（在该式中，R1代表C1-6烷基基团；R2和R3各代表C1-6烷基基团或类似物；R4代表氢原子、C1-6烷基基团、C1-6烷酰基团或C3-8环烷基羰基团。）