N-((3S)-N-(L-asparaginyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-asparagine | 1219835-00-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((3S)-N-(L-asparaginyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-asparagine
• 英文别名: H-Asn-Tic-Asn-OH；(2S)-4-amino-2-[[(3S)-2-[(2S)-2,4-diamino-4-oxobutanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-4-oxobutanoic acid
• CAS: 1219835-00-3
• 化学式: C₁₈H₂₃N₅O₆
• 分子量: 405.411
• InChiKey: LRWAETQVFZPOQA-AVGNSLFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.2
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  199
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-((3S)-N-(Boc-L-asparaginyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-asparagine 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 20.0 ℃ 、100.0 kPa 条件下， 以95%的产率得到N-((3S)-N-(L-asparaginyl)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-L-asparagine
  参考文献：
  名称：

  2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity

  摘要：

  In the preparation of anti-thrombotic agents the 2- and 3-positions of 3S-tetra-hydroisoquinoline-3-carboxylic acid (THIQA) were simultaneously modified with amino acids to form 20 novel N-(3S-N-amino-acyl-1,2,3,4-tetrahydroisoquinoline-3-carbonyl) amino acids (8a-t). On an in vitro platelet aggregation model 8a-t selectively inhibit ADP-induced platelet aggregation and their IC50 values are leas than 3.5 nM. On an extracorporeal circulation of arterioveinos cannula model of rats both orally and intraveously effective doses of 8a-t are less than 30 nmol/kg. Cerius(2) based stereoview of explores 8a-t having highly unfolded conformation. 3D QSAR analysis gives the importance of the unfolded conformation to high in vitro anti-platelet aggregation and in vivo anti-thrombotic potency rational understanding. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.01.009

文献信息

• 2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity
  作者：Xiaoyi Zhang、Wei Wang、Shenling Cheng、Ming Zhao、Meiqing Zheng、Heng Wei Chang、Jianhui Wu、Shiqi Peng

  DOI：10.1016/j.bmc.2010.01.009

  日期：2010.2

  In the preparation of anti-thrombotic agents the 2- and 3-positions of 3S-tetra-hydroisoquinoline-3-carboxylic acid (THIQA) were simultaneously modified with amino acids to form 20 novel N-(3S-N-amino-acyl-1,2,3,4-tetrahydroisoquinoline-3-carbonyl) amino acids (8a-t). On an in vitro platelet aggregation model 8a-t selectively inhibit ADP-induced platelet aggregation and their IC50 values are leas than 3.5 nM. On an extracorporeal circulation of arterioveinos cannula model of rats both orally and intraveously effective doses of 8a-t are less than 30 nmol/kg. Cerius(2) based stereoview of explores 8a-t having highly unfolded conformation. 3D QSAR analysis gives the importance of the unfolded conformation to high in vitro anti-platelet aggregation and in vivo anti-thrombotic potency rational understanding. (C) 2010 Elsevier Ltd. All rights reserved.