2-(4-iodophenyl)thiophene | 72133-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-iodophenyl)thiophene
• 英文别名: 2-iodothiophene；2-(4-Iodo-phenyl)-thiophene
• CAS: 72133-72-3
• 化学式: C₁₀H₇IS
• 分子量: 286.136
• InChiKey: NGZYKRHLXDUIFB-UHFFFAOYSA-N

物化性质

• 沸点：
  319.8±25.0 °C(Predicted)
• 密度：
  1.720±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-iodophenyl)thiophene 生成 2-(4-ethynylphenyl)thiophene
  参考文献：
  名称：

  叔胺充当P / N止痛剂Cu（I）光敏剂的烷基自由基当量

  摘要：

  通过在光氧化还原催化条件下使用P / N杂合性基于Cu（I）的光敏剂，对叔胺作为烷基当量与芳族炔烃进行交叉偶联以获取烯丙基芳烃进行了空前的探索。机理研究表明，该反应可能经历了将原位生成的α-氨基自由基中间体自由基加成至炔烃的反应，然后发生了1,5-氢转移，C–N键断裂以及随之而来的烯丙基自由基物种的异构化。

  DOI：

  10.1021/acs.orglett.0c03236
• 作为产物：
  描述：

  4-(2-噻吩)苯胺 在 盐酸 、 sodium nitrite 、 potassium iodide 作用下， 以 水 为溶剂， 生成 2-(4-iodophenyl)thiophene
  参考文献：
  名称：

  Design and synthesis of boronic acid inhibitors of endothelial lipase

  摘要：

  Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V)LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti-atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the synthesis of alkyl, aryl, or acyl-substituted phenylboronic acids that inhibit EL. Many of the inhibitors evaluated proved to be nearly equally potent against both EL and LPL, but several exhibited moderate to good selectivity for EL. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.043

文献信息

• Pd nanoparticles deposited on Isoniazid grafted multi walled carbon nanotubes: synthesis, characterization and application for Suzuki reaction in aqueous media
  作者：Mahsa Hajighorbani、Malak Hekmati

  DOI：10.1039/c6ra19934h

  日期：——

  The prepared Isoniazide-MWCNTs were used to deposition of Pd NPs as novel nanocatalyst. The catalyst showed high activity in Suzuki coupling reaction of aryl halides (X = I, Br, Cl).

  经过处理的异烟肼-MWCNTs被用于沉积Pd NPs作为新型纳米催化剂。该催化剂在芳基卤化物（X = I, Br, Cl）的铃木偶联反应中表现出高活性。
• [EN] AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE<br/>[FR] INHIBITEURS AZOCYCLIQUES DE L'HYDROLASE DES AMIDES D'ACIDES GRAS
  申请人：DU PONT

  公开号：WO2011072207A1

  公开（公告）日：2011-06-16

  Disclosed are compounds of Formula 1, including all stereoisomers, N oxides, and salts thereof, wherein A, W, X, G, R1, R2, R3, R4, m and n are as defined in the disclosure. Also disclosed are pharmaceutical compositions containing the compounds of Formula 1 and methods for treating a disease or condition mediated by fatty acid amide hydrolase activity comprising applying a therapeutically effective amount of a compound or a composition of the invention.

  公开了Formula 1的化合物，包括所有立体异构体、N氧化物和盐，其中A、W、X、G、R1、R2、R3、R4、m和n的定义如公开的披露所述。还公开了含有Formula 1化合物的药物组合物，以及治疗由脂肪酸酰胺水解酶活性介导的疾病或症状的方法，包括施用本发明的化合物或组合物的治疗有效量。
• Gold-Catalyzed Cascade Reactions of Furan-ynes with External Nucleophiles Consisting of a 1,2-Rearrangement: Straightforward Synthesis of Multi-Substituted Benzo[<i>b</i>]furans
  作者：Ning Sun、Xin Xie、Yuanhong Liu

  DOI：10.1002/chem.201400112

  日期：2014.6.10

  A gold‐catalyzed cycloisomerization of silyl‐protected 2‐(1‐alkynyl)‐2‐alken‐1‐(2‐furanyl)‐1‐ols with various nucleophiles including water, alcohol, aniline, sulfonamide, and electron‐rich arene has been developed. The method provides a highly efficient access to 5,7‐disubstituted or 2,5,7‐trisubstituted benzo[b]furans with a wide diversity of substituents under mild reaction conditions, which are

  甲硅烷基保护的2-（1-炔基）-2-烯基-1-（2-呋喃基）-1-醇与各种亲核试剂（包括水，醇，苯胺，磺酰胺和富电子芳烃）的金催化环异构化反应已开发。该方法提供了以高效率的存取5,7-二取代的或2,5,7-三取代的苯并[ b ]呋喃与取代基的反应条件温和，这是不通过其他方法容易获得下一个广泛的多样性。值得注意的是，在环化过程中，烷基从呋喃环的C2到C3位置发生了有趣的重排。通过以下金辅助的烯丙基取代，可以在其C5位侧链上修饰具有广泛官能团的苯并[ b ]呋喃。
• Palladium-catalyzed cross-coupling of organostannanes with iodanes
  作者：Suk-Ku Kang、Hong-Woo Lee、Jae-Sun Kim、Sang-Chul Choi

  DOI：10.1016/0040-4039(96)00669-7

  日期：1996.5

  The palladium-catalyzed coupling of organostannanes with iodanes(Koser's and Zefirov's reagents) in the presence of palladium catalyst was accomplished at room temperature under aqueous conditions to afford phenyl- or 4-iodophenyl-substituted products depending on the iodanes used.

  在室温下，在水性条件下，在室温下于室温下完成有机锡在钯催化剂存在下钯催化的有机锡与碘酮（Koser's和Zefirov's试剂）的偶联，根据所使用的碘化物，得到苯基或4-碘苯基取代的产物。
• N-Doped porous carbon nanotubes: synthesis and application in catalysis
  作者：Zhenzhen Yang、Zhenghui Liu、Hongye Zhang、Bo Yu、Yanfei Zhao、Huan Wang、Guipeng Ji、Yu Chen、Xinwei Liu、Zhimin Liu

  DOI：10.1039/c6cc09374d

  日期：——

  Uniform N-doped carbon nanotubes were for the first time obtained via a morphology-preserved thermal transformation of organic polymer nanotubes without any additional templates, which acted as a superior metal-free carbon...

  均匀掺杂N的碳纳米管是通过有机聚合物纳米管的形态保留的热转化首次获得的，无需任何其他模板，这些模板可作为优异的无金属碳...