5-fluoro-6-(heptadec-8-enyl)pyrimidin-2,4(1H,3H)-dione | 1464161-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-fluoro-6-(heptadec-8-enyl)pyrimidin-2,4(1H,3H)-dione
• 英文别名: 5-fluoro-6-heptadec-8-enyl-1H-pyrimidine-2,4-dione
• CAS: 1464161-45-2
• 化学式: C₂₁H₃₅FN₂O₂
• 分子量: 366.52
• InChiKey: ZVDSCHKGJKZRHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-(heptadec-8-enyl)pyrimidin-2,4(1H,3H)-dione 在 ammonium cerium (IV) nitrate 、 溶剂黄146 、 lithium fluoride 作用下， 以 乙腈 为溶剂， 反应 18.0h， 以40%的产率得到5-fluoro-6-(heptadec-8-enyl)pyrimidin-2,4(1H,3H)-dione
  参考文献：
  名称：

  Facile synthesis of 6-(heptadec-8-enyl)thiopyrimidines incorporating glycosyl moiety and their antitumor activity

  摘要：

  A facile, convenient, and high yielding synthesis of a new series of pyrimidine N- and S-glycosides incorporating an oleyl residue from readily available starting materials was developed. The key step of this protocol is the formation of a 2-thioxopyrimidine as aglycon which is coupled with an activated cyclic and acyclic halo sugar in the presence of sodium hydride. In addition, 5-fluorouracil analogues containing an oleyl moiety were prepared. The in vitro anticancer activity of the newly synthesized compounds was evaluated against two human cancer cell lines, namely MCF-7 (breast) and HEPG2 (liver) carcinoma. The compounds exhibited moderate to high activities with IC (50) values of 13.2-34.2 mu M for MCF-7 and 16.2-63.8 mu M for HEPG-2 cell lines. 5-Fluorouracil derivatives incorporating a fatty residue are therefore potent against both cell lines.

  DOI：

  10.1007/s00706-013-1069-5