2-[2-fluoro-4-chloro-5-(2-propynyloxy)phenyl]-4-methyl-5-trifluoromethylpyridazin-3-one | 188489-06-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[2-fluoro-4-chloro-5-(2-propynyloxy)phenyl]-4-methyl-5-trifluoromethylpyridazin-3-one
• 英文别名: 2-(4-chloro-2-fluoro-5-propargyloxyphenyl)-4-methyl-5-trifluoromethylpyridazin-3-one；2-[4-chloro-2-fluoro-5-(2-propynyloxy)phenyl]-4-methyl-5-(trifluoromethyl)-3(2H)-pyridazinone；2-(4-chloro-2-fluoro-5-prop-2-ynoxyphenyl)-4-methyl-5-(trifluoromethyl)pyridazin-3-one
• CAS: 188489-06-7
• 化学式: C₁₅H₉ClF₄N₂O₂
• 分子量: 360.695
• InChiKey: ITITUKHFDSNNPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-methyl-5-trifluoromethyl-3-oxo-2,3-dihydropyridazine 、 3-溴丙炔 在 potassium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 0.5h， 生成 2-[2-fluoro-4-chloro-5-(2-propynyloxy)phenyl]-4-methyl-5-trifluoromethylpyridazin-3-one
  参考文献：
  名称：

  Pyridazin-3-one derivatives, their use, and intermediates for their production

  摘要：

  提供具有以下结构式的新型肼酮[2]，其中R3为氢、烷基、卤代烷基或烷氧基烷基；Q为[Q-1]、[Q-2]、[Q-3]、[Q-4]或[Q-5]，用于形成除草剂的活性成分的中间体。

  公开号：

  US06348628B1

文献信息

• Herbicide compositions
  申请人：Sumitomo Chemical Company, Limited

  公开号：US06197727B1

  公开（公告）日：2001-03-06

  The present invention provides herbicide compositions for foliar treatment each containing as active ingredients, a 2-chloro-4-fluoro-5-(4methyl-5-trifluoromethyl-3-pyridazinon-2-chloro-2-yl)phenyl C1-C5 non-cyclic hydrocarbyl ether and one selected from the group consisting of (RS)-2-(4-chloro-2methylphenoxy)propionic acid, 2,4-dichlorophenoxyacetic acid, (4-chloro-2-methyl)phenoxyacetic acid, 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-amino]carbonyl]amino]sulfonyl] benzoate, 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide, ethyl (R)-2-[4(6-chloro-1 3-benzoxazol-2-yloxy)phenoxy]propanoate, methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate, 3,5-dibromo-4-hydroxybenzonitrile, 4-hydroxy-3,5-diiodobenzonitrile, 3-(4-isopropylphenyl)-N′, N′-dimethylurea, N′-(3-chloro-4-methylphenyl)-N,N-dimethylurea and N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide; and a weeding method by foliar treatment of weeds therewith. The present compositions can be used for effective control of various weeds occurring on crop lands or non-crop lands, in which case the herbicidal activity is synergistically enhanced as compared with the cases where the active ingredients are used separately, which makes possible low-dose application, and the herbicidal spectra are expanded, so that a wide variety of weeds can be selectively controlled, particularly on wheat, barley, oat, or rye fields.

  本发明提供了一种除草剂组合物，用于叶面处理，每种组合物均含有以下活性成分：2-氯-4-氟-5-(4-甲基-5-三氟甲基-3-吡啶酮-2-氯-2-基)苯基C1-C5非环烃基醚和从以下组合中选择的一种：(RS)-2-(4-氯-2-甲基苯氧基)丙酸、2,4-二氯苯氧乙酸、(4-氯-2-甲基)苯氧乙酸、2-[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]氨基]磺酰]苯甲酸酯、2-氯-N-[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]苯磺酰]胺、乙基(R)-2-[[4-(6-氯-1,3-苯并噁唑-2-氧基)苯氧基]丙酸酯、甲基(RS)-2-[[4-(2,4-二氯苯氧基)苯氧基]丙酸甲酯、3,5-二溴-4-羟基苯甲腈、4-羟基-3,5-二碘苯甲腈、3-(4-异丙基苯基)-N'，N'-二甲基脲、N'-(3-氯-4-甲基苯基)-N，N-二甲基脲和N-(2,4-二氟苯基)-2-[[3-(三氟甲基)苯氧基]吡啶-3-羧酰胺；以及通过叶面处理除草草本植物的方法。本发明的组合物可用于有效控制作物土地或非作物土地上出现的各种杂草，与单独使用活性成分的情况相比，该除草剂活性具有协同增强作用，从而可以进行低剂量应用，并且除草谱扩展，从而可以选择性地控制各种杂草，特别是在小麦、大麦、燕麦或黑麦田上。
• HERBICIDE COMPOSITIONS
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0968650A1

  公开（公告）日：2000-01-05

  The present invention provides herbicide compositions for foliar treatment each containing as active ingredients, a 2-chloro-4-fluoro-5-(4-methyl-5-trifluoromethyl-3-pyridazinon-2-yl)phenyl C1-C5 non-cyclic hydrocarbyl ether and one selected from the group consisting of (RS)-2-(4-chloro-2-methylphenoxy)propionic acid, 2,4-dichlorophenoxyacetic acid, (4-chloro-2-methyl)phenoxyacetic acid, 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)-amino]carbonyl]amino]sulfonyl] benzoate, 2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide, ethyl (R)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]propanoate, methyl (RS)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionate, 3,5-dibromo-4-hydroxybenzonitrile, 4-hydroxy-3,5-diiodobenzonitrile, 3-(4-isopropylphenyl)-N',N'-dimethylurea, N'-(3-chloro-4-methylphenyl)-N,N-dimethylurea and N-(2,4-difluorophenyl)-2-[3-(trifluoromethyl)phenoxy]-3-pyridinecarboxamide; and a weeding method by foliar treatment of weeds therewith. The present compositions can be used for effective control of various weeds occurring on crop lands or non-crop lands, in which case the herbicidal activity is synergistically enhanced as compared with the cases where the active ingredients are used separately, which makes possible low-dose application, and the herbicidal spectra are expanded, so that a wide variety of weeds can be selectively controlled, particularly on wheat, barley, oat, or rye fields.

  本发明提供了用于叶面处理的除草剂组合物，每种组合物都含有作为活性成分的2-氯-4-氟-5-(4-甲基-5-三氟甲基-3-哒嗪酮-2-基)苯基C1-C5非环烃基醚和选自由(RS)-2-(4-氯-2-甲基苯氧基)丙酸组成的组中的一种、2,4-二氯苯氧乙酸、(4-氯-2-甲基)苯氧乙酸、2-[[[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)-氨基]羰基]氨基]磺酰基]苯甲酸、2-氯-N-[[(4-甲氧基-6-甲基-1,3,5-三嗪-2-基)氨基]羰基]氨基]苯磺酰胺，(R)-2-[4-(6-氯-1,3-苯并恶唑-2-基氧基)苯氧基]丙酸乙酯，(RS)-2-[4-(2,4-二氯苯氧基)苯氧基]丙酸甲酯，3、5-二溴-4-羟基苯腈、4-羟基-3,5-二碘苯腈、3-(4-异丙基苯基)-N',N'-二甲基脲、N'-(3-氯-4-甲基苯基)-N,N-二甲基脲和 N-(2,4-二氟苯基)-2-[3-(三氟甲基)苯氧基]-3-吡啶甲酰胺；以及用其对杂草进行叶面处理的除草方法。 本发明的组合物可用于有效控制作物地或非作物地中出现的各种杂草，在这种情况下，与单独使用活性成分的情况相比，除草活性得到了协同增强，这使得低剂量施用成为可能，并且除草光谱得到了扩展，从而可以选择性地控制多种杂草，特别是小麦、大麦、燕麦或黑麦田中的杂草。
• Method for controlling weeds
  申请人：Matsushima Yutaka

  公开号：US20060009361A1

  公开（公告）日：2006-01-12

  The present invention provides a method for controlling weeds comprising a step of applying one or more compounds to a cultivation area of a plant, to which a gene of cytochrome P450 showing activity of metabolizing a protoporphyrinogen IX oxidase inhibitory-type herbicidal compound has been introduced, wherein said compound to be applied to said area is selected from the group consisting of: (1) flufenpyr-ethyl, (2) 2-[4-chloro-2-fluoro-5-(2-propynyloxy)phenyl]-4-methy-5-(trifluoromethyl)-3(2H)-pyridazinone, (3) carfentrazone-ethyl, and (4) sulfentrazone; and the like.

  本发明提供了一种控制杂草的方法，包括向植物的栽培区施用一种或多种化合物的步骤，该栽培区引入了细胞色素 P450 的基因，该基因显示出代谢原卟啉原 IX 氧化酶抑制型除草化合物的活性，其中向所述栽培区施用的所述化合物选自以下组成的组： (2-[4-氯-2-氟-5-(2-丙炔氧基)苯基]-4-甲基-5-(三氟甲基)-3(2H)-哒嗪酮，(3)carfentrazone-ethyl，以及(4)sulfentrazone；等等。
• PYRIDAZIN-3-ONE DERIVATIVES, THEIR USE, AND INTERMEDIATES FOR THEIR PRODUCTION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0850227A1

  公开（公告）日：1998-07-01
• Method for producing transgenic plants resistant to weed control compounds which disrupt the porphyrin pathways of plants
  申请人：Nakajima Hiroki

  公开号：US20100184597A1

  公开（公告）日：2010-07-22

  A method for producing a transgenic plant which is resistant to a weed control compound is disclosed. In the inventive method, a nucleotide sequence encoding a variant of plant protoporphyrinogen IX oxidase that lacks the FAD binding sequence is introduced into a plant cell. The nucleotide sequence is expressed and the plant cell is regenerated into a transgenic plant.