(2-Bromophenyl)-[5-hydroxy-2-(4-methoxyphenyl)-1-benzofuran-3-yl]methanone | 1221190-21-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: (2-Bromophenyl)-[5-hydroxy-2-(4-methoxyphenyl)-1-benzofuran-3-yl]methanone
• CAS: 1221190-21-1
• 化学式: C₂₂H₁₅BrO₄
• 分子量: 423.263
• InChiKey: PUWKZSGZNNRZEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2-Bromophenyl)-3-(4-methoxyphenyl)propane-1,3-dione 、 对苯醌 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 甲苯 为溶剂， 反应 10.0h， 以79%的产率得到(2-Bromophenyl)-[5-hydroxy-2-(4-methoxyphenyl)-1-benzofuran-3-yl]methanone
  参考文献：
  名称：

  Efficient synthesis of 3-acyl-5-hydroxybenzofurans via copper(II) triflate-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds

  摘要：

  A method to prepare a variety of substituted 3-acyl-5-hydroxybenzofurans efficiently that relies on copper(II) triflate-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds is reported. The reaction was shown to be operationally straightforward and proceeds expediently under mild conditions to give the corresponding products in good to excellent yields (up to 95%) and with complete regioselectivity. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.02.066

文献信息

• Efficient synthesis of 3-acyl-5-hydroxybenzofurans via copper(II) triflate-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds
  作者：Srinivasa Reddy Mothe、Dewi Susanti、Philip Wai Hong Chan

  DOI：10.1016/j.tetlet.2010.02.066

  日期：2010.4

  A method to prepare a variety of substituted 3-acyl-5-hydroxybenzofurans efficiently that relies on copper(II) triflate-catalyzed cycloaddition of unactivated 1,4-benzoquinones with 1,3-dicarbonyl compounds is reported. The reaction was shown to be operationally straightforward and proceeds expediently under mild conditions to give the corresponding products in good to excellent yields (up to 95%) and with complete regioselectivity. (c) 2010 Elsevier Ltd. All rights reserved.