[(5S)-5-amino-5-carboxypentyl]azanium;(2E,4E,6E)-octa-2,4,6-trienoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(5S)-5-amino-5-carboxypentyl]azanium;(2E,4E,6E)-octa-2,4,6-trienoate
• 化学式: C14H24N2O4
• 分子量: 284.35
• InChiKey: OEYUNABQRGCAIM-HQNWCZRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• DIENE COMPOUNDS FOR USE IN HUMAN EPIDERMAL CELL REPAIR AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani Giammaria

  公开号：US20110224298A1

  公开（公告）日：2011-09-15

  The present invention relates to a novel use of compounds having the general formula (I): CH 3 (—CH═CH) n —R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH 2 OH, CH 2 O—CO—R′, CO—OR′, CO—O (−) , where R′ is chosen from among H, the alkyl from C 1 to C 22 , each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.

  本发明涉及具有通式（I）的化合物的新用途： CH3（—CH═CH）n—R  (I) 其中n=2至7，R选择自：CHO，CH2OH，CH2O—CO—R′，CO—OR′，CO—O（−），其中R′选择自：H，C1至C22的烷基。每个通式（I）的化合物被用作活性原料，单独或混合使用，用于制备医药或化妆品组合物，通过细胞角蛋白cK-19介导的角蛋白的生产，提高人类表皮细胞修复活性。
• COMPOSITIONS USEFUL IN THE PREVENTION OR TREATMENT OF SKIN CANCER
  申请人：GIULIANI S.P.A.

  公开号：US20160213635A1

  公开（公告）日：2016-07-28

  The invention relates to compounds of general formula (I): CH 3 —(CH═CH) n —R (I) wherein n=3, 5, 7; R is selected from —CO—OR′, —CO—O (−) , or —CH 2 —O—CO—R′, R′ being selected from H, C 1 -C 22 alkyl or alkenyl.aryl or aralkyl, or sugars; with the proviso that when R is —CH 2 —O—CO—R′ and R′ alkyl, said alkyl being selected from C 1 to C 11 ; and pharmaceutically acceptable salts thereof, preferably such as sodium, potassium, lysine salts, each compound of general formula (I) being used as such or in admixture with one or more of the other ones, for use in the prevention or treatment of skin cancer resulting from DNA damage produced by UV radiation.

  本发明涉及一般式(I)的化合物：CH3—(CH═CH)n—R (I)，其中n=3、5、7；R选择自—CO—OR′、—CO—O(−)或—CH2—O—CO—R′，其中R′选择自H、C1-C22烷基或烯基、芳基或芳基烷基或糖类；但当R为—CH2—O—CO—R′且R′为烷基时，所述烷基选择自C1到C11。所述化合物的药学上可接受的盐，优选为钠、钾、赖氨酸盐，每种一般式(I)的化合物可以单独使用或与其他化合物混合使用，用于预防或治疗由紫外线辐射产生的DNA损伤引起的皮肤癌。
• Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them
  申请人：Giuliani S.p.A.

  公开号：EP2407163A1

  公开（公告）日：2012-01-18

  The present invention relates to compounds having general formula (I):          CH3-(CH=CH)n-R     (I) where: n = 3, 5, 7; R is chosen from -CH2-O-CO-R', -CO-OR' or -CO-O(-), R' is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.

  本发明涉及通式 (I) 的化合物： CH3-(CH=CH)n-R (I) 其中：n = 3、5、7；R 选自 -CH2-O-CO-R'、-CO-OR' 或 -CO-O(-)，R' 选自 H、C1-C22 烷基或烯基、芳基或芳烷基或糖； 及其药学上可接受的盐（如钠盐、钾盐和赖氨酸盐），用作药物或化妆品组合物中的活性成分，用于改善人体皮肤的色素沉着，治疗色素沉着疾病和/或改善皮肤的光保护能力及其晒黑的强度。
• THE USE OF COMPOUNDS TO INHIBIT 5A-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani S.p.A.

  公开号：EP2373302A1

  公开（公告）日：2011-10-12
• THE USE OF COMPOUNDS TO INHIBIT 5alpha-REDUCTASE ENZYME ACTIVITY, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM
  申请人：Giuliani S.p.A.

  公开号：EP2373302B1

  公开（公告）日：2017-09-13