lithium 8-bromooctanoate | 130891-75-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: lithium 8-bromooctanoate
• 英文别名: lithium;8-bromooctanoate
• CAS: 130891-75-7
• 化学式: C₈H₁₄BrO₂*Li
• 分子量: 229.043
• InChiKey: MLLPKWLFVFYTLK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.52
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tert-butyl-[(Z,1S)-1-[(4R,5R)-5-ethynyl-2,2-dimethyl-1,3-dioxolan-4-yl]hex-3-enoxy]-diphenylsilane 、 lithium 8-bromooctanoate 在 正丁基锂 作用下， 反应 0.5h， 以85%的产率得到
  参考文献：
  名称：

  立体选择性合成（11R，12S，13S）-三羟基-（9Z，15Z）-十八碳二烯酸：水稻稻瘟病的一种植物成分

  摘要：

  描述了由D-核糖高度立体选择性地合成标题化合物。

  DOI：

  10.1016/s0040-4039(00)97619-6

文献信息

• Fluorenylalkanoic and Benzoic Acids as Novel Inhibitors of Cell Adhesion Processes in Leukocytes
  作者：Gregory S. Hamilton、Richard E. Mewshaw、Carmen M. Bryant、Ying Feng、Gerda Endemann、Kip S. Madden、Jennifer E. Danczak、John Perumattam、Lawrence W. Stanton

  DOI：10.1021/jm00010a009

  日期：1995.5

  A series of fluoren-9-ylalkanoic and alkylbenzoic acids was prepared as simplified analogues of a previously reported series of antiinflammatory agents which act to inhibit neutrophil recruitment into inflamed tissue. The previous compounds (''leumedins'') contained (alkoxycarbonyl)amino or benzoic acid moieties tethered to a fluorene ring. This functionality was replaced with simple structural elements. The new compounds were, in general, found to be more potent than the earlier series at inhibiting adherence of neutrophils to serum-coated wells or endothelial cells in vitro. Compound 9 was approximately 10-fold more potent than the previously reported FMOC-phenylalanine, of which it is an analogue. Similarly, compound 19 was superior in potency to its first generation progenitor, NPC 16570. The new compounds were shown to inhibit neutrophil adherence under conditions in which adherence is mediated by Mac-1 (CD11b/CD18) and LFA-1 (CD11a/CD18); they thus appear to target beta(2)-integrins in their antiadhesion activity. These compounds provide a departure point for the further development of new cell adhesion inhibitors which should exhibit enhanced potency and a more selective mode of action.
• YADAV, J. S.;CHANDER, MADHAVI C., TETRAHEDRON LETT., 31,(1990) N0, C. 4349-4350
  作者：YADAV, J. S.、CHANDER, MADHAVI C.

  DOI：——

  日期：——