(4Z,7S,8E,10Z,12E,14E,17S,19Z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic acid | 578008-41-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4Z,7S,8E,10Z,12E,14E,17S,19Z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic acid
• CAS: 578008-41-0
• 化学式: C₂₂H₃₂O₅
• 分子量: 376.5
• InChiKey: IKFAUGXNBOBQDM-IALHFOOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• DOCOSAHEXANOIC ACID AS INHIBITOR OF H. PYLORI
  申请人：Touati Eliette

  公开号：US20110064789A1

  公开（公告）日：2011-03-17

  The present invention concerns a method for preventing, modulating or curing in a mammal, the infections with Helicobacter pylori or the symptoms associated with H. pylori infection(s) or related diseases, and/or improving the clinical condition of a mammal infected with H. pylori, or affected by a related disease, comprising administering to a mammal in need thereof an effective amount of one or more DHA related compounds, as well as their use as an adjuvant or co-adjuvant in a method for preventing, modulating or curing in a mammal, the chronical infection with Helicobacter pylori or the symptoms associated with H. pylori infection or related diseases, and/or preventing recurrence as well as relapse of H. pylori infection or related diseases, and/or improving the clinical condition of a mammal infected with H. pylori.
• MODULATORS OF IL-12 AND/OR IL-23 FOR THE PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Becher Burkhard

  公开号：US20130302343A1

  公开（公告）日：2013-11-14

  The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like-molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R-β1, IL-12R-β2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.
• [EN] MODULATORS OF IL-12 AND/OR IL-23 FOR THE PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE<br/>[FR] MODULATEURS D'IL-12 ET/OU IL-23 POUR LA PRÉVENTION OU LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
  申请人：UNIV ZUERICH

  公开号：WO2012093127A2

  公开（公告）日：2012-07-12

  The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of interleukin 12 or 23 and its specific receptor, specifically an antibody, an antibody fragment, an antibody-like- molecule, for the prevention or treatment of Alzheimer's disease. Similarly, siRNA, antisense or transcription factor modulators of gene expression of p19, p35, p40, IL-12R- β1, IL-12R-β2, and/or IL-23R for the prevention or treatment of Alzheimer's disease are provided.