{[8-(3-chloro-5-cyclopropylphenyl)-6-hydroxy[1,2,4]triazolo[1,5-a]pyridine-5-carbonyl]amino}acetic acid hydrochloride | 1262132-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: {[8-(3-chloro-5-cyclopropylphenyl)-6-hydroxy[1,2,4]triazolo[1,5-a]pyridine-5-carbonyl]amino}acetic acid hydrochloride
• 英文别名: 2-[[8-(3-Chloro-5-cyclopropylphenyl)-6-hydroxy-[1,2,4]triazolo[1,5-a]pyridine-5-carbonyl]amino]acetic acid;hydrochloride
• CAS: 1262132-66-0
• 化学式: C₁₈H₁₅ClN₄O₄*ClH
• 分子量: 423.255
• InChiKey: LCDMZFNSBRXKCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.87
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR AND ERYTHROPOIETIN PRODUCTION INDUCER
  申请人：Japan Tobacco, Inc.

  公开号：EP2455381A1

  公开（公告）日：2012-05-23

  The present invention provides a triazolopyridine compound having a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability. The present invention relates to a compound represented by the following formula [I]: wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as a prolyl hydroxylase inhibitor or erythropoietin production-inducing agent containing the compound. The compound of the present invention shows a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability and is useful as a prophylactic or therapeutic agent for various diseases and pathologies (disorders) caused by decreased production of erythropoietin.

  本发明提供了一种具有脯氨酰羟化酶抑制作用和促红细胞生成素诱导能力的三唑并吡啶化合物。本发明涉及一种由下式[I]代表的化合物： 其中各符号如说明书中所定义，或其药学上可接受的盐，或其溶液，以及含有该化合物的脯氨酰羟化酶抑制剂或促红细胞生成素诱导剂。本发明的化合物具有脯氨酰羟化酶抑制作用和促红细胞生成素生成诱导能力，可作为预防或治疗剂用于治疗由促红细胞生成素生成减少引起的各种疾病和病理（紊乱）。
• Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer
  申请人：Japan Tobacco Inc.

  公开号：EP2746282A1

  公开（公告）日：2014-06-25

  The present invention provides a triazolopyridine compound having a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability. The present invention relates to a compound represented by the following formula [I]: wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as a prolyl hydroxylase inhibitor or erythropoietin production-inducing agent containing the compound. The compound of the present invention shows a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability and is useful as a prophylactic or therapeutic agent for various diseases and pathologies (disorders) caused by decreased production of erythropoietin.

  本发明提供了一种具有脯氨酰羟化酶抑制作用和促红细胞生成素诱导能力的三唑并吡啶化合物。本发明涉及一种由下式[I]代表的化合物： 其中各符号如说明书中所定义，或其药学上可接受的盐，或其溶液，以及含有该化合物的脯氨酰羟化酶抑制剂或促红细胞生成素诱导剂。本发明的化合物具有脯氨酰羟化酶抑制作用和促红细胞生成素生成诱导能力，可作为预防或治疗剂用于治疗由促红细胞生成素生成减少引起的各种疾病和病理（紊乱）。