N-(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide | 1443537-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: N-(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide
• 英文别名: N-[ethyl(methyl)sulfamoyl]-4-fluoro-5-[(2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyridine-3-carboxamide
• CAS: 1443537-89-0
• 化学式: C₂₁H₂₂F₃N₅O₃S
• 分子量: 481.499
• InChiKey: FRKYTMHMLKDDDG-MAUKXSAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US20140371217A1

  公开（公告）日：2014-12-18

  The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

  本申请涉及一系列取代吡唑并[1,5-a]吡啶化合物，其用作肌动蛋白激酶受体激酶（Trk）家族蛋白激酶抑制剂，制备方法以及包含这些化合物的药物组合物。
• [EN] SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS<br/>[FR] PYRAZOLO[1,5-A]PYRIDINES SUBSTITUÉES EN TANT QU'INHIBITEURS DU RÉCEPTEUR KINASE LIÉ À LA TROPOMYOSINE (TRK)
  申请人：REDDYS LAB LTD DR

  公开号：WO2013088256A1

  公开（公告）日：2013-06-20

  The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors., method of making and pharmaceutical compositions comprising such compounds.

  本申请涉及一系列取代吡唑并[1,5-a]吡啶化合物，其用作肌浆蛋白受体激酶（Trk）家族蛋白激酶抑制剂，以及制备方法和包含这些化合物的药物组合物。
• Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US10344031B2

  公开（公告）日：2019-07-09

  The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

  本申请涉及一系列取代的吡唑并[1,5-a]吡啶化合物、其作为肌球蛋白受体激酶（Trk）家族蛋白激酶抑制剂的用途、包含此类化合物的制造方法和药物组合物。
• SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP2791138B1

  公开（公告）日：2018-06-06
• Substituted Pyrazolo[1,5-a] Pyridine As Tropomyosin Receptor Kinase (trk) Inhibitors
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：US20180354951A1

  公开（公告）日：2018-12-13

  The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.