H-(L-Nva)5-OMe*HCl | 92900-57-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-(L-Nva)5-OMe*HCl
• CAS: 92900-57-7
• 化学式: C₂₆H₄₉N₅O₆*ClH
• 分子量: 564.166
• InChiKey: BAILZIAFWMCYSD-WUFSUKHGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.85
• 重原子数：
  38.0
• 可旋转键数：
  19.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  168.72
• 氢给体数：
  5.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  H-(L-Nva)5-OMe*HCl 、 [(S)-1-((S)-1-Hydrazinocarbonyl-butylcarbamoyl)-butyl]-carbamic acid tert-butyl ester 生成 (S)-2-{(S)-2-[(S)-2-((S)-2-{(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-pentanoylamino)-pentanoylamino]-pentanoylamino}-pentanoylamino)-pentanoylamino]-pentanoylamino}-pentanoic acid methyl ester
  参考文献：
  名称：

  Synthesis of a Homologous Series of Protected Oligopeptides Derived from L-Norvaline

  摘要：

  AbstractA series of protected L‐norvaline homo‐oligomers from dimer to heptamer was prepared by the dicyclohexylcarbodiimide and acid azide coupling methods. In the course of our synthetic approach t‐butyloxycarbonyl as the N‐protecting and methyl ester as the C‐protecting end groups were used. The oligomers prepared in this manner were characterized and found to be chemically and optically pure. In the accompanying paper an analysis of the conformational preferences in solution of these low molecular weight protected homo‐L‐norvalines in comparison with isomeric L‐valines will be reported.

  DOI：

  10.1002/bscb.19750840403

文献信息

• Folded and extended structures of homooligopeptides from .alpha.,.alpha.-dialkylated .alpha.-amino acids. An infrared absorption and proton nuclear magnetic resonance study
  作者：Gian Maria Bonora、Claudio Toniolo、Benedetto Di Blasio、Vincenzo Pavone、Carlo Pedone、Ettore Benedetti、Ian Lingham、Paul Hardy

  DOI：10.1021/ja00338a025

  日期：1984.12