4-(4-fluorobenzyloxy)-1-(4-(pyrrolidin-1-ylmethyl)phenyl)pyridin-2(1H)-one | 1189572-63-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-fluorobenzyloxy)-1-(4-(pyrrolidin-1-ylmethyl)phenyl)pyridin-2(1H)-one
• 英文别名: 4-[(4-fluorophenyl)methoxy]-1-[4-(pyrrolidin-1-ylmethyl)phenyl]pyridin-2-one
• CAS: 1189572-63-1
• 化学式: C₂₃H₂₃FN₂O₂
• 分子量: 378.446
• InChiKey: RXUSHGWGUPCMPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 4-[(4-fluorobenzyl)oxy]-1-[4-(methanesulfonyloxymethyl)phenyl]pyridin-2(1H)-one 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 4-(4-fluorobenzyloxy)-1-(4-(pyrrolidin-1-ylmethyl)phenyl)pyridin-2(1H)-one
  参考文献：
  名称：

  Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists

  摘要：

  Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy) phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl) phenyl] ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.07.023

文献信息

• Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists
  作者：Makoto Ando、Etsuko Sekino、Yuji Haga、Minoru Moriya、Masahiko Ito、Junko Ito、Hisashi Iwaasa、Akane Ishihara、Akio Kanatani、Norikazu Ohtake

  DOI：10.1016/j.bmcl.2009.07.023

  日期：2009.9

  Novel phenethylpyridone derivatives were identified as potent human melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. A search for surrogates for the 4-(2-aminoethoxy) phenyl moiety of 1 resulted in discovery of 2-[4-(aminomethyl) phenyl] ethyl substructure as in 6a. Successive optimization of the right-hand moiety led to the identification of a number of potent derivatives. (C) 2009 Published by Elsevier Ltd.