N-hydroxy-2,2-bis(4-(methylsulfonamido)phenyl)acetamide | 1194952-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-2,2-bis(4-(methylsulfonamido)phenyl)acetamide
• 英文别名: N-hydroxy-2,2-bis[4-(methanesulfonamido)phenyl]acetamide
• CAS: 1194952-93-6
• 化学式: C₁₆H₁₉N₃O₆S₂
• 分子量: 413.475
• InChiKey: NDCGISZPOIMWEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  158
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  在 羟胺 、 potassium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 N-hydroxy-2,2-bis(4-(methylsulfonamido)phenyl)acetamide
  参考文献：
  名称：

  Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors

  摘要：

  We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen analogue, N-hydroxy-9H-xanthene-9-carboxamide (13), is slightly more selective for HDAC7 with an IC50 of 0.05 mu M. Substitution of 6 allows for the modulation of selectivity and potency amongst the class IIa HDAC isotypes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.010

文献信息

• Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors
  作者：Pierre Tessier、David V. Smil、Amal Wahhab、Silvana Leit、Jubrail Rahil、Zuomei Li、Robert Déziel、Jeffrey M. Besterman

  DOI：10.1016/j.bmcl.2009.08.010

  日期：2009.10

  We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen analogue, N-hydroxy-9H-xanthene-9-carboxamide (13), is slightly more selective for HDAC7 with an IC50 of 0.05 mu M. Substitution of 6 allows for the modulation of selectivity and potency amongst the class IIa HDAC isotypes. (C) 2009 Elsevier Ltd. All rights reserved.