(Z)-N-((Z)-1-(4-n-butylphenylimino)-4,7-bis(n-octyloxy)isindolin-3-ylidene)-4-butylbenzeneamine | 1382918-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (Z)-N-((Z)-1-(4-n-butylphenylimino)-4,7-bis(n-octyloxy)isindolin-3-ylidene)-4-butylbenzeneamine
• 英文别名: N-(4-butylphenyl)-3-(4-butylphenyl)imino-4,7-dioctoxyisoindol-1-amine
• CAS: 1382918-01-5
• 化学式: C₄₄H₆₃N₃O₂
• 分子量: 666.003
• InChiKey: HYHRXBDUHGJFJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.7
• 重原子数：
  49
• 可旋转键数：
  25
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  55.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-正丁基苯胺 、 3,6-二辛氧基-1,2-苯二甲腈 在 calcium chloride 作用下， 以 正丁醇 为溶剂， 反应 15.0h， 以81%的产率得到(Z)-N-((Z)-1-(4-n-butylphenylimino)-4,7-bis(n-octyloxy)isindolin-3-ylidene)-4-butylbenzeneamine
  参考文献：
  名称：

  Synthesis and characterization of membrane stable bis(arylimino)isoindole dyes and their potential application in nano-biotechnology

  摘要：

  A synthetic methodology of preparing novel membrane stable, responsive dyes is revealed in this manuscript. 1,3-Bis(arylimino)isoindole dyes were synthesized and their properties to undergo intramolecular hydrogen bonding was studied with fluorescence spectroscopy in varying solvent polarities. Based on the functional moieties, compound that is capable of hydrogen donor and acceptor interactions produces predominant photoexcitation in comparison to the responsive dyes that lack these functionalities. These dyes, by the virtue of the presence of long chain acyl groups could be incorporated stably within the phospholipids membrane of core-shell nanoparticles. Nanoparticle was 'cracked' to release the dye from a hydrophobic to a hydrophilic environment. A significant change in florescence intensity was then observed, indicating the direct change in effect of intramolecular hydrogen bonding based on solvent polarity changes. This unique study provided implications of many further applications toward nanomedicine and nano-biotechnology. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.05.128