(R)-2-[2-(2-Amino-2-methyl-propionylamino)-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid phenylamide hydrochloride | 185055-96-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2-[2-(2-Amino-2-methyl-propionylamino)-3-(1H-indol-3-yl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid phenylamide hydrochloride
• 英文别名: 2-[(2R)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-indol-3-yl)propanoyl]-N-phenyl-3,4-dihydro-1H-isoquinoline-6-carboxamide;hydrochloride
• CAS: 185055-96-3
• 化学式: C₃₁H₃₃N₅O₃*ClH
• 分子量: 560.096
• InChiKey: YNPJTXALRYLEDX-HZPIKELBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.19
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  4

文献信息

• DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE
  申请人：PFIZER INC.

  公开号：EP0828754A1

  公开（公告）日：1998-03-18
• BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
  申请人：Signal Pharmaceuticals, Inc.

  公开号：EP1497277A1

  公开（公告）日：2005-01-19
• [EN] DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE<br/>[FR] DIPEPTIDES FAVORISANT LA SECRETION DE L'HORMONE DE CROISSANCE
  申请人：PFIZER INC.

  公开号：WO1996038471A1

  公开（公告）日：1996-12-05

  (EN) Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis.(FR) L'invention se rapporte aux composés de la formule (I). Il s'agit de mimétiques des peptides favorisant la secrétion de l'hormone de croissance, qui sont utiles pour le traitement et la prévention de l'ostéoporose.
• [EN] DIPEPTIDES WHICH PROMOTE RELEASE OF GROWTH HORMONE<br/>[FR] DIPEPTIDES STIMULANT LA LIBERATION DE L'HORMONE DE CROISSANCE
  申请人：PFIZER, INC.

  公开号：WO1996035713A1

  公开（公告）日：1996-11-14

  (EN) Compounds of formula (I) are growth hormone releasing peptide mimetics which are useful for the treatment and prevention of osteoporosis.(FR) Les composés de formule (I) sont des substances mimétiques peptidiques libérant l'hormone de croissance, utiles pour traiter et prévenir l'ostéoporose.
• [EN] BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] COMPOSES BENZOPYRANONE, COMPOSITIONS CONTENANT CES COMPOSES ET METHODES DE TRAITEMENT ASSOCIEES
  申请人：SIGNAL PHARM INC

  公开号：WO2003089422A1

  公开（公告）日：2003-10-30

  Benzopyranone compounds having the structure of formula (I), are disclosed. The compounds of formula (I), wherein R1 is H, can be prepared by demethylation of the corresponding phenolic methyl ether. The compounds are useful for treating a bone-resorbing disease, cancer, arthritis or an estrogen-related condition such as breast cancer, osteoporosis, endometriosis, cardiovascular disease, hypercholesterolemia, prostatic hypertrophy, prostatic carcinomas, obesity, hot flashes, skin effects, mood swings, memory loss, and adverse reproductive effects associated with exposure to environmental chemicals or natural hormonal imbalances.