| 1250866-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1250866-26-2
• 化学式: C₂₀H₃₄I₂N₂O₅Si₂
• 分子量: 692.48
• InChiKey: KDXPQFBTBXQOCW-WRWLIDTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.52
• 重原子数：
  31.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  71.81
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  、 三甲基铝 在 水 、 碳酸氢钠 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 2.0h， 以73.2%的产率得到
  参考文献：
  名称：

  Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics

  摘要：

  Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2'-modified nucleosides. In particular, disubstitution at the C-2' position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2'-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.

  DOI：

  10.1021/ol101482h
• 作为产物：
  描述：

  (6aR,8R,9R,9aS)-8-(4,5-diiodo-1H-imidazol-1-yl)-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-9-ol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以66.9%的产率得到
  参考文献：
  名称：

  Tricyclic 2′-C-Modified Nucleosides as Potential Anti-HCV Therapeutics

  摘要：

  Promising biological activity in a number of therapeutic areas has been reported for both tricyclic nucleosides and 2'-modified nucleosides. In particular, disubstitution at the C-2' position of nucleosides has resulted in significant activity against the hepatitis C virus (HCV). Combining this with the observation that tricyclic nucleosides developed in our laboratory have been shown to inhibit the RNA-dependent RNA polymerase NS5B led to the design of a series of 2'-modified tricyclic nucleosides. Details of the synthesis, structural characterization, and preliminary biological results are reported.

  DOI：

  10.1021/ol101482h