Methyl 2-[[4-(dimethylamino)phenyl]methyl-(2-methoxy-2-oxoethyl)amino]-2-oxoacetate | 1164369-40-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-[[4-(dimethylamino)phenyl]methyl-(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
• CAS: 1164369-40-7
• 化学式: C₁₅H₂₀N₂O₅
• 分子量: 308.334
• InChiKey: KXNDPWBGLDZZSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  76.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  甲基戊酰氯 、 (4-Dimethylamino-benzylamino)-acetic acid methyl ester 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以35%的产率得到Methyl 2-[[4-(dimethylamino)phenyl]methyl-(2-methoxy-2-oxoethyl)amino]-2-oxoacetate
  参考文献：
  名称：

  N-草酰甘氨酸及其衍生物作为Jumonji C-域组蛋白赖氨酸脱甲基酶抑制剂的合成及活性

  摘要：

  合成了N- Oxalylglycine（NOG）衍生物，并评估了其对组蛋白赖氨酸脱甲基酶活性的抑制作用。NOG和化合物1在酶分析中抑制组蛋白赖氨酸脱甲基酶JMJD2A，2C和2D，它们的二甲基酯前药DMOG和21在细胞分析中发挥组蛋白赖氨酸甲基化活性。

  DOI：

  10.1016/j.bmcl.2009.03.098

文献信息

• COMPOUNDS FOR USE IN A METHOD OF PREVENTING OR TREATING VIRAL INFECTION
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP2595613B1

  公开（公告）日：2019-01-09
• METHOD OF PREVENTING OR TREATING VIRAL INFECTION
  申请人：Department of Health and Human Services The United States of America, as Represented by the Secretary,

  公开号：US20130123344A1

  公开（公告）日：2013-05-16

  Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.
• [EN] METHOD OF PREVENTING OR TREATING VIRAL INFECTION<br/>[FR] MÉTHODE DESTINÉE À PRÉVENIR OU À TRAITER UNE INFECTION VIRALE
  申请人：US HEALTH

  公开号：WO2012012627A1

  公开（公告）日：2012-01-26

  Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein or pharmaceutically acceptable salts thereof. Also disclosed is a method of preventing or treating a viral infection of a host, comprising administering to the host an effective amount of an inhibitor of the JMJD2 family of histone demethylases, for example, a compound of the formula (I). The viral infection may be a primary infection, reactivation of a virus after latency in a host, or may be in a mammal that has undergone, is undergoing, or will undergo immunosuppressive therapy.
• Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors
  作者：Shohei Hamada、Tae-Dong Kim、Takayoshi Suzuki、Yukihiro Itoh、Hiroki Tsumoto、Hidehiko Nakagawa、Ralf Janknecht、Naoki Miyata

  DOI：10.1016/j.bmcl.2009.03.098

  日期：2009.5

  N-Oxalylglycine (NOG) derivatives were synthesized, and their inhibitory effect on histone lysine demethylase activity was evaluated. NOG and compound 1 inhibited histone lysine demethylases JMJD2A, 2C and 2D in enzyme assays, and their dimethyl ester prodrugs DMOG and 21 exerted histone lysine methylating activity in cellular assays.

  合成了N- Oxalylglycine（NOG）衍生物，并评估了其对组蛋白赖氨酸脱甲基酶活性的抑制作用。NOG和化合物1在酶分析中抑制组蛋白赖氨酸脱甲基酶JMJD2A，2C和2D，它们的二甲基酯前药DMOG和21在细胞分析中发挥组蛋白赖氨酸甲基化活性。