5-{[(1Z)-5,6-dimethyl-3-oxo-1-({[4-(trifluoromethyl)phenyl]sulfonyl}imino)-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-8-yl]thio}-N-hexylpentanamide | 476426-46-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{[(1Z)-5,6-dimethyl-3-oxo-1-({[4-(trifluoromethyl)phenyl]sulfonyl}imino)-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-8-yl]thio}-N-hexylpentanamide
• 英文别名: ITZ-7；5-[5,6-dimethyl-3-oxo-1-[[4-(trifluoromethyl)phenyl]sulfonylamino]imidazo[5,1-c][1,4]thiazin-8-yl]sulfanyl-N-hexylpentanamide
• CAS: 476426-46-7
• 化学式: C₂₆H₃₃F₃N₄O₄S₃
• 分子量: 618.766
• InChiKey: TUAXYZMHLQHSFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  40
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  167
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  正己胺 、 5-{[(1Z)-5,6-dimethyl-3-oxo-1-({[4-(trifluoromethyl)phenyl]sulfonyl}imino)-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-8-yl]thio}pentanoic acid 在 氰基磷酸二乙酯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以4.6%的产率得到5-{[(1Z)-5,6-dimethyl-3-oxo-1-({[4-(trifluoromethyl)phenyl]sulfonyl}imino)-2,3-dihydro-1H-imidazo[5,1-c][1,4]thiazin-8-yl]thio}-N-hexylpentanamide
  参考文献：
  名称：

  ITZ-1, a Client-Selective Hsp90 Inhibitor, Efficiently Induces Heat Shock Factor 1 Activation

  摘要：

  ITZ-1 is a chondroprotective agent that inhibits interleukin-1 beta-induced matrix metalloproteinase-13 (MMP-13) production and suppresses nitric oxide-induced chondrocyte death. Here we describe its mechanisms of action. Heat shock protein 90 (Hsp90) was identified as a specific ITZ-1-binding protein. Almost all known Hsp90 inhibitors have been reported to bind to the Hsp90 N-terminal ATP-binding site and to simultaneously induce degradation and activation of its multiple client proteins. However, within the Hsp90 client proteins, ITZ-1 strongly induces heat shock factor-1 (HSF1) activation and causes mild Raf-1 degradation, but scarcely induces degradation of a broad range of Hsp90 client proteins by binding to the Hsp90 C terminus. These results may explain ITZ-1's inhibition of MMP-13 production, its cytoprotective effect, and its lower cytotoxicity. These results suggest that ITZ-1 is a client-selective Hsp90 inhibitor.

  DOI：

  10.1016/j.chembiol.2009.12.012