(2S)-1,2-dihydroxyundecane-3,4-dione | 1187311-17-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S)-1,2-dihydroxyundecane-3,4-dione
• CAS: 1187311-17-6
• 化学式: C₁₁H₂₀O₄
• 分子量: 216.277
• InChiKey: LRNHDMIDDUALIA-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (S)-1,2-cyclohexylidenedioxy-3,4-undecadione 在 硫酸 、 水 作用下， 反应 24.0h， 生成 (2S)-1,2-dihydroxyundecane-3,4-dione
  参考文献：
  名称：

  Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs

  摘要：

  Autoinducer-2 (AI-2) has been suggested to serve as a universal interspecies quorum sensing signaling molecule. We have synthesized a set of AI-2 analogs with small incremental changes in alkyl substitution on C-2 and evaluated them for their agonistic and antagonistic potential as quorum sensing (QS) attenuators in two different bacterial species: Pseudomonas aeruginosa and Vibrio harveyi. Unexpectedly, several of the analogs were found to function as synergistic QS agonists in V. harveyi, while two of these analogs inhibit QS in P. aeruginosa. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.163

文献信息

• Inhibition of Pseudomonas aeruginosa quorum sensing by AI-2 analogs
  作者：Hadas Ganin、Xu Tang、Michael M. Meijler

  DOI：10.1016/j.bmcl.2009.03.163

  日期：2009.7

  Autoinducer-2 (AI-2) has been suggested to serve as a universal interspecies quorum sensing signaling molecule. We have synthesized a set of AI-2 analogs with small incremental changes in alkyl substitution on C-2 and evaluated them for their agonistic and antagonistic potential as quorum sensing (QS) attenuators in two different bacterial species: Pseudomonas aeruginosa and Vibrio harveyi. Unexpectedly, several of the analogs were found to function as synergistic QS agonists in V. harveyi, while two of these analogs inhibit QS in P. aeruginosa. (C) 2009 Elsevier Ltd. All rights reserved.