N-benzyl-[4-(diphenylphosphino)phenoxy]acetamide | 1429125-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-[4-(diphenylphosphino)phenoxy]acetamide
• CAS: 1429125-55-2
• 化学式: C₂₇H₂₄NO₂P
• 分子量: 425.467
• InChiKey: ZQZRNMKXAPVRNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.14
• 重原子数：
  31.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  N-benzyl-[4-(diphenylphosphino)phenoxy]acetamide 、 methyl 6-azido-6-deoxy-2,3,4-tri-O-methyl-α-D-glucopyranose 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Implementing the “Catch-and-Release” Concept into a Simple Method for Regioselective Cyclodextrin Modification

  摘要：

  Differentiation of specific positions in axial-symmetrical cyclodextrins (CDs), exhibiting a dense display of identical functional groups, is challenging. A novel strategy toward this goal that exploits a solid matrix to display the complementary reagent functionalities sufficiently far from each other to prevent CDs from reacting through more than one site is reported. Using a "catch-and-release" process based on the Staudinger reaction, the utility of this concept to easily produce complex CD functionalization patterns in one pot and without any purification step is demonstrated.

  DOI：

  10.1021/ol400641n
• 作为产物：
  描述：

  二苯基膦 在 palladium diacetate 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 12.08h， 生成 N-benzyl-[4-(diphenylphosphino)phenoxy]acetamide
  参考文献：
  名称：

  Implementing the “Catch-and-Release” Concept into a Simple Method for Regioselective Cyclodextrin Modification

  摘要：

  Differentiation of specific positions in axial-symmetrical cyclodextrins (CDs), exhibiting a dense display of identical functional groups, is challenging. A novel strategy toward this goal that exploits a solid matrix to display the complementary reagent functionalities sufficiently far from each other to prevent CDs from reacting through more than one site is reported. Using a "catch-and-release" process based on the Staudinger reaction, the utility of this concept to easily produce complex CD functionalization patterns in one pot and without any purification step is demonstrated.

  DOI：

  10.1021/ol400641n