6-Sulfanyl-L-norleucine | 91724-74-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-Sulfanyl-L-norleucine
• 英文别名: (2S)-2-amino-6-sulfanylhexanoic acid
• CAS: 91724-74-2
• 化学式: C₆H₁₃NO₂S
• 分子量: 163.24
• InChiKey: HBMWPJLCTYKAGL-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  64.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• THREE-FUNCTIONAL PSEUDO-PEPTIDIC REAGENT, AND USES AND APPLICATIONS THEREOF
  申请人：Clave Guillaume

  公开号：US20100221749A1

  公开（公告）日：2010-09-02

  The invention relates to a three-functional pseudo-peptidic reagent, to the various uses thereof, in particular for preparing bioluminescent reagents or optionally luminescent bio-conjugates, to the use of said reagents and bio-conjugates for functionalising solid substrates, and to the use of solid substrates thus functionalised in the detection of molecules of interest.

  本发明涉及一种三功能假肽试剂，以及其各种用途，特别是用于制备生物发光试剂或可选的发光生物共轭物，使用该试剂和生物共轭物对固体基质进行功能化，以及使用这样功能化的固体基质检测感兴趣的分子。
• PIF1-LIKE HELICASE AND APPLICATION THEREOF
  申请人：Qitan Technology Ltd., Beijing

  公开号：EP4063382A9

  公开（公告）日：2022-11-16

  A modified Pifl-like helicase, a construct containing a Pifl-like helicase, and an application thereof in characterizing a target polynucleotide or controlling the movement of a target polynucleotide passing through pores. The present invention also relates to a method for characterizing a target polynucleotide or controlling the movement of a target polynucleotide passing through pores. The Pifl-like helicase can effectively control the movement of a polynucleotide passing through pores and increase the accuracy of a chain sequencing process.

  一种改进的类 Pifl 螺旋酶、一种含有类 Pifl 螺旋酶的构建体及其在表征目标多核苷酸或控制目标多核苷酸穿过孔隙的运动中的应用。本发明还涉及一种表征目标多核苷酸或控制目标多核苷酸穿过孔隙的方法。Pifl 样螺旋酶可有效控制穿过孔隙的多核苷酸的运动，提高链测序过程的准确性。
• Method for attaching one or more polynucleotide binding proteins to a target polynucleotide
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10385389B2

  公开（公告）日：2019-08-20

  The invention relates to new methods of attaching one or more polynucleotide binding proteins to a target polynucleotide. The invention also relates to new methods of characterizing target polynucleotides.

  本发明涉及将一种或多种多核苷酸结合蛋白连接到目标多核苷酸上的新方法。本发明还涉及表征目标多核苷酸的新方法。
• Modified helicases
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10724018B2

  公开（公告）日：2020-07-28

  The invention relates to a new method of characterising a target polynucleotide. The method uses a pore and a Dda helicase. The helicase controls the movement of the target polynucleotide through the pore. The invention also relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

  本发明涉及一种表征目标多核苷酸的新方法。该方法使用一个孔和一个 Dda 螺旋酶。螺旋酶控制目标多核苷酸通过孔道。本发明还涉及经修饰的 Dda 螺旋酶，它可用于控制多核苷酸的运动，尤其适用于多核苷酸的测序。
• Modified enzymes
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US11180741B2

  公开（公告）日：2021-11-23

  The invention relates to modified Dda helicases which can be used to control the movement of polynucleotides and are particularly useful for sequencing polynucleotides.

  本发明涉及经修饰的 Dda 螺旋酶，可用于控制多核苷酸的移动，尤其适用于多核苷酸的测序。