3-溴-N,N-二正丙基苯胺 | 1020180-09-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-溴-N,N-二正丙基苯胺
• 英文名称: 3-bromo-N,N-di-n-propylaniline
• 英文别名: 3-bromo-N,N-dipropylaniline
• CAS: 1020180-09-9
• 化学式: C₁₂H₁₈BrN
• 分子量: 256.186
• InChiKey: OCUQFEDQKVJVSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,3-二溴苯 、 二正丙胺 在 tris-(dibenzylideneacetone)dipalladium(0) R-(+)-1,1'-联萘-2,2'-双二苯膦 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以51%的产率得到3-溴-N,N-二正丙基苯胺
  参考文献：
  名称：

  Palladium-catalyzed monoamination of dihalogenated benzenes

  摘要：

  The palladium-catalyzed monoamination of symmetric dibromobenzenes can be performed using a catalyst based on Pd(2)dba(3) and BINAP in the presence of NaO(t-Bu). The analogous transformation of non-symmetric bromoiodobenzenes is most effectively performed with Xantphos as the ligand, while reactions with BINAP were non-selective. These transformations can be scaled uneventfully to >10 g quantities. They do not require drybox or Schlenk techniques, and all reagents are weighed out in air. The resulting monobromoanilines are versatile intermediates for further synthetic transformations. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.070

文献信息

• QUENCHER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US20170342031A1

  公开（公告）日：2017-11-30

  A quencher is disclosed having a compound represented by the following general formula (1): wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An − represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).

  一种淬灭剂被公开，该淬灭剂具有以下一般公式(1)表示的化合物： 其中R5各自独立代表一个卤素原子、一个烷基团、一个烷氧基团、一个烷硫基团、一个带有或不带有取代基的氨基团、一个羟基、一个芳基团、一个芳氧基团或一个芳烷基团；R6代表一个具有可聚合不饱和基团、一个羟基或类似基团的集团；Y1代表一个氧原子或类似；An代表一个阴离子；Ar1代表一个特定的环结构；*和**代表结合位置；Ar2代表一个苯环、一个萘环或一个蒽环；n1代表一个特定的整数； 并且一般公式(1)中的以下结构(1-10)是一个不对称结构； (其中R5、Y1、Ar1、Ar2、n1、*和**与上述描述相同)。
• GRAFT POLYMER, RESIN COLORED MATTER, METHOD FOR PRODUCING SAME, AND RESIN COMPOSITION CONTAINING RESIN COLORED MATTER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP3165541A1

  公开（公告）日：2017-05-10

  Provided are: a graft polymer and a colored resin that are free from color migration or fading caused by bleed-out after coloring, which is a defect of a dye, without impairing vivid color development and transparency of the dye; a method for producing the same; and a resin composition containing the colored resin. The present invention relates to: (1) a graft polymer that has a polyolefin (A) as the main chain, and a polymer (B) polymerized a dye (b) having a radical reactive functional group, in a side chain; (2) the graft polymer which is characterized in that the dye (b) having the radical reactive functional group is a cationic rhodamine derivative, a cationic triarylmethane-type dye derivative or a cationic cyanine-type dye derivative, having an ethylenically unsaturated group; (3) a colored resin consisting of the graft polymer; as well as (4) a method for producing the colored resin, which is characterized by mixing the polyolefin (A), the dye (b) having the radical reactive functional group, and the radical reaction initiator (C), and subjecting a radical reaction of the mixture; and the like.

  本发明提供了：一种接枝聚合物和有色树脂，它们在不损害染料的鲜艳显色性和透明性的情况下，不会因着色后的渗色（染料的缺陷）而导致颜色迁移或褪色；一种生产方法；以及一种含有该有色树脂的树脂组合物。 本发明涉及(1)一种接枝聚合物，其主链为聚烯烃(A)，侧链为聚合了具有自由基活性官能团的染料(b)的聚合物(B)；(2)该接枝聚合物，其特征在于具有自由基活性官能团的染料(b)是阳离子罗丹明衍生物、阳离子三芳基甲烷型染料衍生物或阳离子氰基型染料衍生物，具有乙烯不饱和基团；(3) 由接枝聚合物组成的有色树脂；以及 (4) 生产有色树脂的方法，其特征在于将聚烯烃 (A)、具有自由基活性官能团的染料 (b) 和自由基反应引发剂 (C) 混合，并使混合物发生自由基反应；等等。
• [EN] QUENCHER<br/>[FR] EXTINCTEUR DE FLUORESCENCE<br/>[JA] 消光剤
  申请人：WAKO PURE CHEM IND LTD

  公开号：WO2016098889A1

  公开（公告）日：2016-06-23

  　従来の消光剤は、蛍光性を有する化合物の蛍光発光を十分に抑制し得るほどの消光能を有していない。そこで、本発明は、キサンテン系染料をはじめとする蛍光性を有する化合物に対し、その蛍光を十分に消光し得る消光剤の提供を課題とする。　本発明は、下記一般式（１）で示される化合物からなる消光剤等に関する。｛式中、Ｒ５はそれぞれ独立して、ハロゲン原子、アルキル基、アルコキシ基、アルキルチオ基、置換基を有するもしくは無置換のアミノ基、ヒドロキシル基、アリール基、アリールオキシ基又はアリールアルキル基を表し、Ｒ６は、重合性不飽和基を有する基、ヒドロキシル基等を表し、Ｙ１は、酸素原子等を表し、Ａｎ-は、アニオンを表し、Ａｒ１は、特定の環構造を表し、＊及び＊＊は、結合位置を表し、Ａｒ２は、ベンゼン環、ナフタレン環又はアントラセン環を表し、ｎ１は特定の整数を表す。ただし、一般式（１）における下記の構造（１－１０）は非対称構造である；（式中、Ｒ５、Ｙ１、Ａｒ１、Ａｒ２、ｎ１、＊及び＊＊は上記と同じ。）。｝
• [EN] NOVEL COMPOUND HAVING INHIBITORY ACTIVITY AGAINST PENDRIN, AND PHARMACEUTICAL USES THEREOF<br/>[FR] NOUVEAU COMPOSÉ PRÉSENTANT UNE ACTIVITÉ INHIBITRICE CONTRE LA PENDRINE, ET SES UTILISATIONS PHARMACEUTIQUES<br/>[KO] 펜드린 억제 활성을 갖는 신규 화합물 및 이의 의약 용도
  申请人：[en]YONSEI UNIVERSITY, UNIVERSITY - INDUSTRY FOUNDATION (UIF);[ko]연세대학교 산학협력단

  公开号：WO2022260494A1

  公开（公告）日：2022-12-15

  본 발명은 펜드린 억제 활성을 갖는 신규 화합물 및 이의 의약 용도에 관한 것으로, 하기 화학식 1로 표시되는 화합물, 이의 E- 또는 Z-이성질체, 이의 광학이성질체, 이의 전구체, 이의 약학적으로 허용가능한 염, 이의 용매화물 또는 이의 2종의 이성질체 혼합물 및 이의 펜드린 억제 활성을 이용한 호흡기 질환 예방, 개선 또는 치료용 조성물 및 이뇨용 조성물을 제공한다.
• Palladium-catalyzed monoamination of dihalogenated benzenes
  作者：Simon Birksø Larsen、Benny Bang-Andersen、Tommy Nørskov Johansen、Morten Jørgensen

  DOI：10.1016/j.tet.2008.01.070

  日期：2008.3

  The palladium-catalyzed monoamination of symmetric dibromobenzenes can be performed using a catalyst based on Pd(2)dba(3) and BINAP in the presence of NaO(t-Bu). The analogous transformation of non-symmetric bromoiodobenzenes is most effectively performed with Xantphos as the ligand, while reactions with BINAP were non-selective. These transformations can be scaled uneventfully to >10 g quantities. They do not require drybox or Schlenk techniques, and all reagents are weighed out in air. The resulting monobromoanilines are versatile intermediates for further synthetic transformations. (C) 2008 Elsevier Ltd. All rights reserved.