顺式-6-甲基-哌啶-1,3-二甲酸1-叔丁酯 | 1253200-82-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 顺式-6-甲基-哌啶-1,3-二甲酸1-叔丁酯
• 英文名称: cis-6-Methyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
• 英文别名: (3R,6S)-6-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]piperidine-3-carboxylic acid
• CAS: 1253200-82-6
• 化学式: C₁₂H₂₁NO₄
• 分子量: 243.3
• InChiKey: TZCMQIKRCZLVQN-DTWKUNHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20160221948A1

  公开（公告）日：2016-08-04

  The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R 1 represents optionally substituted C 1-4 alkyl, n shows integer of 1 to 4, R 2 represents optionally substituted C 1-4 alkyl or hydrogen atom, R 3 represents optionally substituted C 1-4 alkyl, R 4a , R 4b , R 4c , and R 4d , similarly or differently, represent optionally substituted C 6-14 aryl, optionally substituted C 1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C 6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

  本发明提供了一种由下式(I)表示的化合物或其药用可接受的盐： [其中，R1表示可选地取代的C1-4烷基，n表示1到4的整数，R2表示可选地取代的C1-4烷基或氢原子，R3表示可选地取代的C1-4烷基，R4a、R4b、R4c和R4d，相同或不同，表示可选地取代的C6-14芳基，可选地取代的C1-4烷基，或氢原子等，A表示可选地取代的C6-14芳基或可选地取代的5至11成员的杂芳基]。
• 2-ALKYL PIPERIDINE MGLUR5 RECEPTOR MODULATORS
  申请人：Mercer Swati P.

  公开号：US20120040998A1

  公开（公告）日：2012-02-16

  The present invention is directed to 2-alkylpiperidines which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及2-烷基哌啶类化合物，其为代谢型谷氨酸受体的正向变构调节剂，特别是mGluR5受体，并且在治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病方面有用。本发明还涉及包含这些化合物的药物组合物和使用这些化合物和组合物在预防或治疗代谢型谷氨酸受体参与的这些疾病方面。
• DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS
  申请人：Pfizer Inc.

  公开号：US20150087585A1

  公开（公告）日：2015-03-26

  Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H-imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.

  本文描述了嘌呤的衍生物，Formula I的3H-咪唑并[4,5-b]嘧啶和1H-咪唑并[4,5-d]吡嗪，它们抑制二酰基甘油酰基转移酶2（DGAT2）的活性，并在动物治疗相关疾病中的用途。
• NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
  申请人：Sumitomo Chemical Company Limited

  公开号：EP3045448A1

  公开（公告）日：2016-07-20

  The present invention provides a compound represented by the following formula (I) or its pharmaceutically acceptable salt: [wherein, R1 represents optionally substituted C1-4 alkyl, n shows integer of 1 to 4, R2 represents optionally substituted C1-4 alkyl or hydrogen atom, R3 represents optionally substituted C1-4 alkyl, R4a, R4b, R4c, and R4d, similarly or differently, represent optionally substituted C6-14 aryl, optionally substituted C1-4 alkyl, or hydrogen atom and the like, A represents optionally substituted C6-14 aryl or optionally substituted 5 to 11 membered heteroaryl].

  本发明提供了下式 (I) 所代表的化合物或其药学上可接受的盐： [其中，R1 代表任选取代的 C1-4 烷基，n 表示 1 至 4 的整数，R2 代表任选取代的 C1-4 烷基或氢原子，R3 代表任选取代的 C1-4 烷基，R4a、R4b、R4c 和 R4d 类似或不同地代表任选取代的 C6-14 芳基、任选取代的 C1-4 烷基或氢原子等，A 代表任选取代的 C6-14 芳基或任选取代的 5 至 11 分子杂芳基]。
• US9296745B2
  申请人：——

  公开号：US9296745B2

  公开（公告）日：2016-03-29