1-cyclobutyl-5-methyl-2-[4-(propan-2-ylamino)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile | 1247935-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-cyclobutyl-5-methyl-2-[4-(propan-2-ylamino)phenyl]-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile
• 英文别名: 1-Cyclobutyl-5-methyl-2-[4-(propan-2-ylamino)phenyl]pyrrolo[2,3-b]pyridine-3-carbonitrile
• CAS: 1247935-09-6
• 化学式: C₂₂H₂₄N₄
• 分子量: 344.459
• InChiKey: UTLKKLSPASKKMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  53.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT
  申请人：Maccoss Malcolm

  公开号：US20120135999A1

  公开（公告）日：2012-05-31

  The present invention is directed to compounds and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

  本发明涉及化合物及其形式和制药组合物，可用于治疗病毒感染，或通过调节病毒复制来影响病毒活性。
• [EN] COMPOUNDS AND METHODS FOR ANTIVIRAL TREATMENT<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR UN TRAITEMENT ANTIVIRAL
  申请人：SCHERING CORP

  公开号：WO2010117935A1

  公开（公告）日：2010-10-14

  The present invention is directed to compounds of formula (I) and forms and pharmaceutical compositions thereof useful for treating a viral infection, or for affecting viral activity by modulating viral replication.

  本发明涉及式(I)的化合物、形式和药物组合物，用于治疗病毒感染，或通过调节病毒复制来影响病毒活性。
• COMBINATIONS OF A HCV INHIBITOR SUCH AS BICYCLIC PYRROLE DERIVATIVES AND A THERAPEUTIC AGENT
  申请人：Lahser Frederick C.

  公开号：US20120087893A1

  公开（公告）日：2012-04-12

  The present invention is directed to a combination product for treating or ameliorating hepatitis C virus (HCV) infection or disorders or symptoms associated therewith in a subject in need thereof comprising, a HCV inhibitor and one or more therapeutic agents selected from either or both a HCV protease inhibitor and one or more different therapeutic agents administered in combination in an effective amount to the subject.
• US9198907B2
  申请人：——

  公开号：US9198907B2

  公开（公告）日：2015-12-01
• US9593108B2
  申请人：——

  公开号：US9593108B2

  公开（公告）日：2017-03-14