| 1255764-05-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1255764-05-6
• 化学式: C₁₆H₂₄O₃
• 分子量: 264.365
• InChiKey: XIYAXZHKYAPVEZ-WWGRRREGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.03
• 重原子数：
  19.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以86%的产率得到(2R,3S,4R)-2-[(4-methoxyphenyl)methoxy]-3,4-dimethylhex-5-enal
  参考文献：
  名称：

  (−)-Lytophilippine A: Synthesis of a C1−C18 Building Block

  摘要：

  The convergent enantioselective synthesis of a protected C1-C18 building block for the total synthesis of (-)-lytophilippine A was achieved. A catalytic asymmetric Gosteli-Claisen rearrangement and an Evans aldol reaction served as key C/C-connecting transformations during the assembling of the C1-C7 subunit (10 steps from 4, 29%). The synthesis of the C8-C18 segment was achieved utilizing D-galactose as inexpensive ex-chiral-pool starting material (15 steps, 15%). The merger of the subunits was accomplished by a remarkably efficient sequence consisting of esterification and ring-closing metathesis (five steps, 56%).

  DOI：

  10.1021/ol1023008
• 作为产物：
  描述：

  在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以97%的产率得到
  参考文献：
  名称：

  (−)-Lytophilippine A: Synthesis of a C1−C18 Building Block

  摘要：

  The convergent enantioselective synthesis of a protected C1-C18 building block for the total synthesis of (-)-lytophilippine A was achieved. A catalytic asymmetric Gosteli-Claisen rearrangement and an Evans aldol reaction served as key C/C-connecting transformations during the assembling of the C1-C7 subunit (10 steps from 4, 29%). The synthesis of the C8-C18 segment was achieved utilizing D-galactose as inexpensive ex-chiral-pool starting material (15 steps, 15%). The merger of the subunits was accomplished by a remarkably efficient sequence consisting of esterification and ring-closing metathesis (five steps, 56%).

  DOI：

  10.1021/ol1023008