(exo) (1R,6S)-bicyclo[4.1.0]heptane-7-carboxamide | 90154-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (exo) (1R,6S)-bicyclo[4.1.0]heptane-7-carboxamide
• 英文别名: Bicyclo[4.1.0]heptane-7-carboxamide
• CAS: 90154-89-5
• 化学式: C₈H₁₃NO
• 分子量: 139.197
• InChiKey: GGLINYPAJRAUAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• SUBSTITUTED BICYCLO [4.1.0] HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES
  申请人：Looft Jan

  公开号：US20100189863A1

  公开（公告）日：2010-07-29

  The present invention relates to the use of a compound of the Formula (I) wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 denote in each case independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, or an alkenyl radical with 2 to 6 C atoms, with the proviso that at least one of the radicals R 1 , R 2 , R 7 and R 8 and at least one further of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are not hydrogen, wherein independently of one another also two of the radicals R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 can together denote a bridge with one or more bridge C atoms; Y 1 and Y 2 denote independently of one another hydrogen, methyl or ethyl; and R a and R b denote independently of one another hydrogen, an alkyl radical with 1 to 6 C atoms, an alkenyl radical with 2 to 6 C atoms or a cycloalkyl radical with 3 to 6 C atoms as a food flavor substance.

  本发明涉及使用式（I）化合物，其中：R1、R2、R3、R4、R5、R6、R7和R8各自独立地表示氢、具有1至6个碳原子的烷基基团或具有2至6个碳原子的烯基基团，但至少其中一个基团R1、R2、R7和R8以及至少另一个基团R1、R2、R3、R4、R5、R6、R7和R8不是氢，其中R1、R2、R3、R4、R5、R6、R7和R8的两个基团也可以独立地共同表示具有一个或多个桥接碳原子的桥；Y1和Y2各自独立地表示氢、甲基或乙基；以及Ra和Rb各自独立地表示氢、具有1至6个碳原子的烷基基团、具有2至6个碳原子的烯基基团或具有3至6个碳原子的环烷基团，作为食品香味物质。
• PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1749002B1

  公开（公告）日：2009-05-27
• SUBSTITUTED BICYCLOÝ4.1.0¨HEPTANE-7-CARBOXYLIC ACID AMIDES AND DERIVATIVES THEREOF AS FOOD FLAVOR SUBSTANCES
  申请人：Symrise GmbH & Co. KG

  公开号：EP2079322A1

  公开（公告）日：2009-07-22
• STOFFGEMISCHE
  申请人：Symrise AG

  公开号：EP3383200B1

  公开（公告）日：2019-11-06
• Substituted Cyclopropanecarboxylic acid (3-methyl-cyclohexyl)amide as flavoring substance
  申请人：Looft Jan

  公开号：US20080292763A1

  公开（公告）日：2008-11-27

  The present invention relates to the use of a compound of formula (I) or a mixture of compounds of formula (I) wherein: R 1 , R 2 , and R 3 are independently H or an alkyl group having 1 to 3 C-atom, wherein at least one of R 1 , R 2 , and R 3 is not H; R 4 is H, an alkyl group having 1 to 6 C-atom, or an alkenyl group having 2 to 6 C-atom; R 5 , R 6 , R 7 , and R 8 are independently H or methyl; and R 9 is H, an alkyl group having 5 to 12 C-atoms, or an alkenyl group having 5 to 12 C-atoms; as a flavoring substance or mixture of flavoring substances.