(3S)-[3,3-dimethyl-(1S)-(morpholine-4-carbonyl)-butoxycarbonylamino]-4-hydroxy-butyric acid tert-butyl ester | 850796-97-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-[3,3-dimethyl-(1S)-(morpholine-4-carbonyl)-butoxycarbonylamino]-4-hydroxy-butyric acid tert-butyl ester
• 英文别名: tert-butyl (3S)-3-[[(2S)-4,4-dimethyl-1-morpholin-4-yl-1-oxopentan-2-yl]oxycarbonylamino]-4-hydroxybutanoate
• CAS: 850796-97-3
• 化学式: C₂₀H₃₆N₂O₇
• 分子量: 416.515
• InChiKey: OMUPTAJQEVWEGX-GJZGRUSLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• INHIBITORS OF CATHEPSIN S
  申请人：Liu Hong

  公开号：US20080021025A1

  公开（公告）日：2008-01-24

  The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

  本发明提供了化合物、组合物和方法，用于选择性抑制蛋白酶S。在一个优选方面，当至少存在另一种蛋白酶同工酶时，选择性地抑制蛋白酶S。本发明还提供了通过选择性抑制蛋白酶S治疗患者的疾病状态的方法。
• US7297714B2
  申请人：——

  公开号：US7297714B2

  公开（公告）日：2007-11-20
• [EN] INHIBITORS OF CATHEPSIN S<br/>[FR] INHIBITEURS DE LA CATHEPSINE S
  申请人：IRM LLC

  公开号：WO2005039496A2

  公开（公告）日：2005-05-06

  The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.