sodium;4-methoxycarbonyl-2,3-diphenyl-3H-1,2-oxazol-5-olate | 1260501-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - N-苯基羟胺
• 英文名称: sodium;4-methoxycarbonyl-2,3-diphenyl-3H-1,2-oxazol-5-olate
• CAS: 1260501-63-0
• 化学式: C₁₇H₁₄NO₄*Na
• 分子量: 319.292
• InChiKey: KMZAWWJNCDTYQH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.07
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodiodimethylmalonate 、 N-(benzylidene)aniline N-oxide 以 甲醇 为溶剂， 以71%的产率得到sodium;4-methoxycarbonyl-2,3-diphenyl-3H-1,2-oxazol-5-olate
  参考文献：
  名称：

  The stereoselective synthesis of highly functionalized tertiary 3-aminoindoles/anilines or dihydropyrroles from C-(3-indolyl)-N-aryl and C,N-diaryl nitrones

  摘要：

  We report on the novel properties of nitrones including their transformations via reactions with sodium malonates to give functionalized stereodefined derivatives of tertiary 3-aminoindoles or anilines, as well as fully-substituted dihydropyrroles. The outcome of the reactions is dependent mainly upon the nature of the starting C-nitrone substituent and solvent used. The formation of a new carbon nitrogen bond in the obtained amines occurs via a nucleophilic 1,2-aryl/3-indolyl shift from C to the adjacent nitrogen. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.10.045