(4R,5R)-2-Cyclohex-1-enyl-4,5-diphenyl-[1,3]dioxolane | 396718-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4R,5R)-2-Cyclohex-1-enyl-4,5-diphenyl-[1,3]dioxolane
• 英文别名: (4R,5R)-2-(cyclohexen-1-yl)-4,5-diphenyl-1,3-dioxolane
• CAS: 396718-76-6
• 化学式: C₂₁H₂₂O₂
• 分子量: 306.404
• InChiKey: UZSPCGIEOGJLET-WOJBJXKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (4R,5R)-2-Cyclohex-1-enyl-4,5-diphenyl-[1,3]dioxolane 在 4-二甲氨基吡啶 作用下， 以 乙醚 为溶剂， 生成 Acetic acid (1R,2R)-1,2-diphenyl-2-[(R)-2-phenyl-cyclohex-(E)-ylidenemethoxy]-ethyl ester
  参考文献：
  名称：

  Regio- and diastereoselective SN2′ or SN2″ reactions on chiral acetals of cyclic aldehydes promoted by PhCu, BF3

  摘要：

  The regio- and diastereoselectivity of the addition of PhCu, BF3 reagent on chiral acetals derived from several mono or dienic aldehydes was studied. It as found that monoethylenic acetals react regio- and diastercoselectively via Lin overall anti S(N)2' reaction. The regioselectivity observed with the dienic acetals seems to be strongly dependent on the nature of the acetal. In all cases the S(N)2'' reaction was the result of an anti process. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00319-6
• 作为产物：
  描述：

  1-cyclohexene-1-carboxaldehyde 、 氢胺 在 硝酸铵 、 原甲酸三乙酯 、 4-甲基苯磺酸吡啶 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 6.0h， 以52%的产率得到(4R,5R)-2-Cyclohex-1-enyl-4,5-diphenyl-[1,3]dioxolane
  参考文献：
  名称：

  Regio- and diastereoselective SN2′ or SN2″ reactions on chiral acetals of cyclic aldehydes promoted by PhCu, BF3

  摘要：

  The regio- and diastereoselectivity of the addition of PhCu, BF3 reagent on chiral acetals derived from several mono or dienic aldehydes was studied. It as found that monoethylenic acetals react regio- and diastercoselectively via Lin overall anti S(N)2' reaction. The regioselectivity observed with the dienic acetals seems to be strongly dependent on the nature of the acetal. In all cases the S(N)2'' reaction was the result of an anti process. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(01)00319-6