(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1-(2-morpholinoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetoxy)ethyl)pyridine-1-oxide | 1431565-24-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1-(2-morpholinoethyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetoxy)ethyl)pyridine-1-oxide
• 英文别名: [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] 2-[1-(2-morpholin-4-ylethyl)-2,4-dioxoquinazolin-3-yl]acetate
• CAS: 1431565-24-0
• 化学式: C₃₄H₃₄Cl₂F₂N₄O₈
• 分子量: 735.569
• InChiKey: KZFXDRCWCXTQPW-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  50
• 可旋转键数：
  15
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  123
• 氢给体数：
  0
• 氢受体数：
  11

文献信息

• DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：EP2768822A2

  公开（公告）日：2014-08-27
• [EN] DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] DÉRIVÉS D'ALCOOLS 1-PHÉNYL-2-PYRIDINYLALKYLIQUES UTILISÉS COMME INHIBITEURS DE PHOSPHODIESTÉRASE
  申请人：CHIESI FARMA SPA

  公开号：WO2013057013A2

  公开（公告）日：2013-04-25

  The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.