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N-(tert-butoxycarbonyl)-6-aminohexyl methacrylate | 1235885-08-1

中文名称
——
中文别名
——
英文名称
N-(tert-butoxycarbonyl)-6-aminohexyl methacrylate
英文别名
6-(tert-butoxycarbonylamino)hexyl methacrylate;6-[(2-Methylpropan-2-yl)oxycarbonylamino]hexyl 2-methylprop-2-enoate
N-(tert-butoxycarbonyl)-6-aminohexyl methacrylate化学式
CAS
1235885-08-1
化学式
C15H27NO4
mdl
——
分子量
285.384
InChiKey
MOFAMNUZHLLSRF-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.2
  • 重原子数:
    20
  • 可旋转键数:
    11
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.73
  • 拓扑面积:
    64.6
  • 氢给体数:
    1
  • 氢受体数:
    4

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为产物:
    参考文献:
    名称:
    包含伯氨基和叔氨基侧基的阳离子甲基丙烯酸酯共聚物:通过RAFT聚合,DNA缩合和体外基因转染进行受控合成
    摘要:
    合成了包含不同数量的伯氨基和叔氨基侧基的全系列阳离子甲基丙烯酸酯共聚物,并进行了体外基因转染的研究。两种不同类型的甲基丙烯酸酯共聚物,聚(2-甲基丙烯酸(2-(二甲基氨基)乙基)/甲基丙烯酸氨基乙酯[P(DMAEMA / AEMA)]和聚(甲基丙烯酸2-(二甲基氨基)乙基酯)/甲基丙烯酸氨基己酯[P(DMAEMA / AHMA)]通过甲基丙烯酸二甲基氨基乙酯(DMAEMA)与N-(叔丁氧基羰基)甲基丙烯酸氨基乙酯(Boc-AEMA)或N-(叔)的可逆加成-断裂链转移(RAFT)共聚反应获得-丁氧基羰基)甲基丙烯酸氨基己酯(Boc-AHMA),然后进行酸脱保护。凝胶渗透色谱(GPC)测量表明,Boc保护的甲基丙烯酸酯共聚物的M n在16.1–23.0 kDa范围内,低多分散性为1.12–1.26。通过单体进料比很好地控制了共聚物的组成。动态光散射和琼脂糖凝胶电泳测量表明,这些PDMAEMA共
    DOI:
    10.1002/pola.24064
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文献信息

  • Fluorescence color change of supramolecular polymer networks controlled by crown ether‐cation recognition
    作者:Weiwei Han、Hailan Tian、Taotao Qiang、Hu Wang、Pi Wang
    DOI:10.1002/chem.202303569
    日期:2024.2.26
    A fluorescent supramolecular polymer networks based on crown ether-cation recognition was fabricated. The host dimer M1 which exhibits blue fluorescence was prepared by decorating benzo[15]crown-5 with a quinoline group. M1 can crosslink the ammonium cations-grafted polymer P1 to form a supramolecular polymer networks through host-guest recognition, accompanied by the transformation of blue fluorescence
    制备了基于冠醚阳离子识别的荧光超分子聚合物网络。通过用喹啉基团修饰苯并[15]crown-5来制备表现出蓝色荧光的主体二聚体M1。 M1可以通过主客体识别使阳离子接枝聚合物P1交联形成超分子聚合物网络,并伴随蓝色荧光转变为黄色荧光。
  • Compositions and methods to treat disease
    申请人:REGENTS OF THE UNIVERSITY OF MINNESOTA
    公开号:US11382929B2
    公开(公告)日:2022-07-12
    Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.
    本文公开了包含膜溶解聚合物或其盐和化疗剂或其盐的组合物,以及包含膜溶解聚合物或其盐和屏蔽聚合物或其盐的组合物。还公开了用这些组合物治疗癌症等疾病的方法和用途。
  • Cationic Spacer Arm Design Strategy for Control of Antimicrobial Activity and Conformation of Amphiphilic Methacrylate Random Copolymers
    作者:Edmund F. Palermo、Satyavani Vemparala、Kenichi Kuroda
    DOI:10.1021/bm300342u
    日期:2012.5.14
    Antimicrobial and hemolytic activities of amphiphilic random copolymers were modulated by the structure of the cationic side chain spacer arms, including 2-aminoethylene, 4-aminobutylene, and 69 6-aminohexylene groups. Cationic amphiphilic random copolymers with ethyl methacrylate (EMA) comonomer were prepared with a range of comonomer fractions, and the library of copolymers was screened for antimicrobial and hemolytic activities. Copolymers with 4-aminobutylene cationic side chains showed an order of magnitude enhancement in their antimicrobial activity relative to those with 2-aminoethylene spacer arms, without causing adverse hemolysis. When the spacer arms were further elongated to hexylene, the copolymers displayed potent antimicrobial and hemolytic activities. The 4 aminobutylene side chain appears to be the optimal spacer arm length for maximal antimicrobial potency and minimal hemolysis, when combined with hydrophobic ethylmethacrylate in a roughly 70/30 ratio. The copolymers displayed relatively rapid bactericidal kinetics and broad-spectrum activity against a panel of Gram-positive and Gram-negative bacteria. The effect of the spacer arms on the polymer conformation in the membrane-bound state was investigated by molecular dynamics simulations. The polymer backbones adopt an extended chain conformation, parallel to the membrane surface. A facially amphiphilic conformation at the membrane surface was observed, with the primary ammonium groups localized at the lipid phoshophate region and the nonpolar side chains of EMA comonomers buried in the hydrophobic membrane environment. This study demonstrates that the antimicrobial activity and molecular conformation of amphiphilic methacrylate random copolymers can be modulated by adjustment of cationic side chain spacer arms.
  • COMPOSITIONS AND METHODS TO TREAT DISEASE
    申请人:REGENTS OF THE UNIVERSITY OF MINNESOTA
    公开号:US20200405746A1
    公开(公告)日:2020-12-31
    Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.
  • COMBINATION TUMOR TREATMENT
    申请人:Boston Scientific Scimed, Inc.
    公开号:US20210290300A1
    公开(公告)日:2021-09-23
    In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.
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