Fluorescence color change of supramolecular polymer networks controlled by crown ether‐cation recognition
作者:Weiwei Han、Hailan Tian、Taotao Qiang、Hu Wang、Pi Wang
DOI:10.1002/chem.202303569
日期:2024.2.26
A fluorescent supramolecularpolymer networks based on crown ether-cation recognition was fabricated. The host dimer M1 which exhibits blue fluorescence was prepared by decorating benzo[15]crown-5 with a quinoline group. M1 can crosslink the ammonium cations-grafted polymer P1 to form a supramolecularpolymer networks through host-guest recognition, accompanied by the transformation of blue fluorescence
Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.
Cationic Spacer Arm Design Strategy for Control of Antimicrobial Activity and Conformation of Amphiphilic Methacrylate Random Copolymers
作者:Edmund F. Palermo、Satyavani Vemparala、Kenichi Kuroda
DOI:10.1021/bm300342u
日期:2012.5.14
Antimicrobial and hemolytic activities of amphiphilic random copolymers were modulated by the structure of the cationic side chain spacer arms, including 2-aminoethylene, 4-aminobutylene, and 69 6-aminohexylene groups. Cationic amphiphilic random copolymers with ethyl methacrylate (EMA) comonomer were prepared with a range of comonomer fractions, and the library of copolymers was screened for antimicrobial and hemolytic activities. Copolymers with 4-aminobutylene cationic side chains showed an order of magnitude enhancement in their antimicrobial activity relative to those with 2-aminoethylene spacer arms, without causing adverse hemolysis. When the spacer arms were further elongated to hexylene, the copolymers displayed potent antimicrobial and hemolytic activities. The 4 aminobutylene side chain appears to be the optimal spacer arm length for maximal antimicrobial potency and minimal hemolysis, when combined with hydrophobic ethylmethacrylate in a roughly 70/30 ratio. The copolymers displayed relatively rapid bactericidal kinetics and broad-spectrum activity against a panel of Gram-positive and Gram-negative bacteria. The effect of the spacer arms on the polymer conformation in the membrane-bound state was investigated by molecular dynamics simulations. The polymer backbones adopt an extended chain conformation, parallel to the membrane surface. A facially amphiphilic conformation at the membrane surface was observed, with the primary ammonium groups localized at the lipid phoshophate region and the nonpolar side chains of EMA comonomers buried in the hydrophobic membrane environment. This study demonstrates that the antimicrobial activity and molecular conformation of amphiphilic methacrylate random copolymers can be modulated by adjustment of cationic side chain spacer arms.
COMPOSITIONS AND METHODS TO TREAT DISEASE
申请人:REGENTS OF THE UNIVERSITY OF MINNESOTA
公开号:US20200405746A1
公开(公告)日:2020-12-31
Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.
COMBINATION TUMOR TREATMENT
申请人:Boston Scientific Scimed, Inc.
公开号:US20210290300A1
公开(公告)日:2021-09-23
In some aspects, the present disclosure pertains to methods of treating a tissue volume comprising (a) administering an implantable composition comprising a releasable membrane-active agent to a target site such that the membrane-active agent is locally released to the tissue volume and (b) performing irreversible, reversible and/or thermal treatment by application of a pulsed electric field to the tissue volume. In other aspects, the present disclosure pertains to embolic compositions that comprise releasable membrane-active agents.