1-butyl-3-[(3-fluorobenzyl)sulfonyl]pyrazin-2(1H)-one | 1187017-11-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-butyl-3-[(3-fluorobenzyl)sulfonyl]pyrazin-2(1H)-one
• 英文别名: 1-Butyl-3-[(3-fluorophenyl)methylsulfonyl]pyrazin-2-one
• CAS: 1187017-11-3
• 化学式: C₁₅H₁₇FN₂O₃S
• 分子量: 324.376
• InChiKey: CDCUKJKWLYZIMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES<br/>[FR] DÉRIVÉS DE PYRAZINONE COMME STIMULATEURS DE LA SÉCRÉTION D'INSULINE, LEURS PROCÉDÉS D'OBTENTION ET LEUR UTILISATION POUR LE TRAITEMENT DU DIABÈTE
  申请人：MERCK PATENT GMBH

  公开号：WO2009109259A1

  公开（公告）日：2009-09-11

  The present invention relates to pyrazinone derivatives of formula (I), wherein n, R1, R2, R3 and R4 are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.

  本发明涉及式（I）的吡嗪酮衍生物，其中n、R1、R2、R3和R4如权利要求1所定义，作为胰岛素分泌刺激剂。该发明还涉及这些吡嗪酮衍生物的制备和应用，用于糖尿病和相关病理的预防和/或治疗。
• PYRAZINONE DERIVATIVES AS INSULIN SECRETON STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES
  申请人：Merck Patent GmbH

  公开号：US20140100235A1

  公开（公告）日：2014-04-10

  The present invention relates to pyrazinone derivatives of formula (I), wherein n, R1, R2, R3 and R4 are as defined in claim 1 , as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.

  本发明涉及式（I）的吡嗪酮衍生物，其中n，R1，R2，R3和R4如权利要求1所定义，作为促进胰岛素分泌的刺激剂。本发明还涉及这些吡嗪酮衍生物的制备和使用，用于糖尿病和相关病理的预防和/或治疗。
• Pyrazinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
  申请人：Botton Gérard

  公开号：US20110015210A1

  公开（公告）日：2011-01-20

  The present invention relates to pyrazinone derivatives of formula (I), wherein n, R1, R2, R3 and R4 are as defined in claim 1 , as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.

  本发明涉及式(I)的吡嗪酮衍生物，其中n，R1，R2，R3和R4如权利要求1所定义，作为促进胰岛素分泌的刺激剂。本发明还涉及这些吡嗪酮衍生物的制备和用于预防和/或治疗糖尿病和相关病理的用途。
• PYRAZINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES
  申请人：Merck Patent GmbH

  公开号：EP2250156A1

  公开（公告）日：2010-11-17
• US8637522B2
  申请人：——

  公开号：US8637522B2

  公开（公告）日：2014-01-28