N-[3-(2-amino-1H-imidazol-5-yl)propyl]-4,5-dibromo-1-[(4-methoxyphenyl)methyl]pyrrole-2-carboxamide;hydrochloride | 1060677-17-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-[3-(2-amino-1H-imidazol-5-yl)propyl]-4,5-dibromo-1-[(4-methoxyphenyl)methyl]pyrrole-2-carboxamide;hydrochloride
• CAS: 1060677-17-9
• 化学式: C₁₉H₂₁Br₂N₅O₂*ClH
• 分子量: 547.677
• InChiKey: JHDHNCCUDIBTAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.16
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-[3-(2-amino-1H-imidazol-5-yl)propyl]-4,5-dibromo-1-[(4-methoxyphenyl)methyl]pyrrole-2-carboxamide 在 盐酸 作用下， 以 甲醇 、 乙醚 、 水 为溶剂， 生成 N-[3-(2-amino-1H-imidazol-5-yl)propyl]-4,5-dibromo-1-[(4-methoxyphenyl)methyl]pyrrole-2-carboxamide;hydrochloride
  参考文献：
  名称：

  Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

  摘要：

  Bacteria of the genus Acinetobacter spp. are rapidly emerging as problematic pathogens in healthcare settings. This is exacerbated by the bacteria's ability to form robust biofilms. Marine natural products incorporating a 2-aminoimidazole (2-AI) motif, namely from the oroidin class of marine alkaloids, have served as a unique scaffold for developing molecules that have the ability to inhibit and disperse bacterial biofilms. Herein we present the anti-biofilm activity of a small library of second generation oroidin analogues against the bacterium Acinetobacter baumannii. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.089

文献信息

• Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii
  作者：Justin J. Richards、Catherine S. Reed、Christian Melander

  DOI：10.1016/j.bmcl.2008.06.089

  日期：2008.8

  Bacteria of the genus Acinetobacter spp. are rapidly emerging as problematic pathogens in healthcare settings. This is exacerbated by the bacteria's ability to form robust biofilms. Marine natural products incorporating a 2-aminoimidazole (2-AI) motif, namely from the oroidin class of marine alkaloids, have served as a unique scaffold for developing molecules that have the ability to inhibit and disperse bacterial biofilms. Herein we present the anti-biofilm activity of a small library of second generation oroidin analogues against the bacterium Acinetobacter baumannii. (c) 2008 Elsevier Ltd. All rights reserved.