benzyl (3R,6R,7R,8S,8aR)-7-ethenyl-8-ethyl-5-oxo-3-phenyl-6-prop-2-enyl-3,7,8,8a-tetrahydro-2H-[1,3]oxazolo[3,2-a]pyridine-6-carboxylate | 1190081-88-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl (3R,6R,7R,8S,8aR)-7-ethenyl-8-ethyl-5-oxo-3-phenyl-6-prop-2-enyl-3,7,8,8a-tetrahydro-2H-[1,3]oxazolo[3,2-a]pyridine-6-carboxylate
• CAS: 1190081-88-9
• 化学式: C₂₈H₃₁NO₄
• 分子量: 445.558
• InChiKey: ZQDLDUBTAKLWSX-KCALTQBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl (3R,6R,7R,8S,8aR)-7-ethenyl-8-ethyl-5-oxo-3-phenyl-6-prop-2-enyl-3,7,8,8a-tetrahydro-2H-[1,3]oxazolo[3,2-a]pyridine-6-carboxylate 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  An Unexpected Oxidation in the Generation of Cyclopenta[c]piperidines by Ring-Closing Metathesis

  摘要：

  Ring-closing metathesis reaction of dienes A (n = 1, R = CO2R') leads to fused cyclopentenones C instead of the expected cyclopentene derivatives B. RCM reaction of the other dienes A takes place satisfactorily, affording the expected fused cycloalkene derivatives B. Cyclohexene B (n = 2, R = CO2R') also undergoes oxidation to the corresponding cyclohexenone C.

  DOI：

  10.1021/ol901704f
• 作为产物：
  描述：

  (3R,7R,8S,8aR)-6-(benzyloxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 、 3-溴丙烯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以62%的产率得到benzyl (3R,6R,7R,8S,8aR)-7-ethenyl-8-ethyl-5-oxo-3-phenyl-6-prop-2-enyl-3,7,8,8a-tetrahydro-2H-[1,3]oxazolo[3,2-a]pyridine-6-carboxylate
  参考文献：
  名称：

  An Unexpected Oxidation in the Generation of Cyclopenta[c]piperidines by Ring-Closing Metathesis

  摘要：

  Ring-closing metathesis reaction of dienes A (n = 1, R = CO2R') leads to fused cyclopentenones C instead of the expected cyclopentene derivatives B. RCM reaction of the other dienes A takes place satisfactorily, affording the expected fused cycloalkene derivatives B. Cyclohexene B (n = 2, R = CO2R') also undergoes oxidation to the corresponding cyclohexenone C.

  DOI：

  10.1021/ol901704f

文献信息

• An Unexpected Oxidation in the Generation of Cyclopenta[<i>c</i>]piperidines by Ring-Closing Metathesis
  作者：Mercedes Amat、Elisa Brunaccini、Begoña Checa、Maria Pérez、Núria Llor、Joan Bosch

  DOI：10.1021/ol901704f

  日期：2009.10.1

  Ring-closing metathesis reaction of dienes A (n = 1, R = CO2R') leads to fused cyclopentenones C instead of the expected cyclopentene derivatives B. RCM reaction of the other dienes A takes place satisfactorily, affording the expected fused cycloalkene derivatives B. Cyclohexene B (n = 2, R = CO2R') also undergoes oxidation to the corresponding cyclohexenone C.