4,5-Dimethoxy-2-(2,3,4-trimethoxy-benzoylamino)-benzoic acid ethyl ester | 343783-88-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,5-Dimethoxy-2-(2,3,4-trimethoxy-benzoylamino)-benzoic acid ethyl ester
• 英文别名: Ethyl 4,5-dimethoxy-2-[(2,3,4-trimethoxybenzoyl)amino]benzoate
• CAS: 343783-88-0
• 化学式: C₂₁H₂₅NO₈
• 分子量: 419.431
• InChiKey: WKIHCKXXWCRBRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  6-硝基藜芦酸 在 palladium on activated charcoal 硫酸 、 氢气 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 4,5-Dimethoxy-2-(2,3,4-trimethoxy-benzoylamino)-benzoic acid ethyl ester
  参考文献：
  名称：

  Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells

  摘要：

  A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00717-4

文献信息

• Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells
  作者：Haruhisa Ogita、Yoshiaki Isobe、Haruo Takaku、Rena Sekine、Yuso Goto、Satoru Misawa、Hideya Hayashi

  DOI：10.1016/s0960-894x(00)00717-4

  日期：2001.2

  A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.