N-[(2R,3S)-3-hydroxy-11-methyldodecan-2-yl]acetamide | 1160519-96-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2R,3S)-3-hydroxy-11-methyldodecan-2-yl]acetamide
• 英文别名: clavaminol N
• CAS: 1160519-96-9
• 化学式: C₁₅H₃₁NO₂
• 分子量: 257.417
• InChiKey: PRFSPTJBPXYTAI-HIFRSBDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[(2R,3S)-3-hydroxy-11-methyldodecan-2-yl]acetamide 在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 生成 (2R,3S)-2-amino-11-methyldodecan-3-ol
  参考文献：
  名称：

  Clavaminols G–N, six new marine sphingoids from the Mediterranean ascidian Clavelina phlegraea

  摘要：

  An exhaustive examination of the chemical constituents of the Mediterranean ascidian Clavelina phlegraea led to the isolation of clavaminols G-N (1-6), a new series of amino alcohols, which expand the family of modified marine sphingoids. Structures of the novel compounds 1-6 have been elucidated by spectroscopic analysis and chemical derivatization: bioactivities of compounds 1-6 have also been investigated and comparison of their pharmacological properties with those of previously isolated clavaminols A-F allowed us to perform an assessment of simple structure-activity relationships. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.056

文献信息

• Clavaminols G–N, six new marine sphingoids from the Mediterranean ascidian Clavelina phlegraea
  作者：Anna Aiello、Ernesto Fattorusso、Antonella Giordano、Marialuisa Menna、Carmen Navarrete、Eduardo Muñoz

  DOI：10.1016/j.tet.2009.03.056

  日期：2009.5

  An exhaustive examination of the chemical constituents of the Mediterranean ascidian Clavelina phlegraea led to the isolation of clavaminols G-N (1-6), a new series of amino alcohols, which expand the family of modified marine sphingoids. Structures of the novel compounds 1-6 have been elucidated by spectroscopic analysis and chemical derivatization: bioactivities of compounds 1-6 have also been investigated and comparison of their pharmacological properties with those of previously isolated clavaminols A-F allowed us to perform an assessment of simple structure-activity relationships. (C) 2009 Elsevier Ltd. All rights reserved.