盐酸依替卡因 | 36637-19-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 盐酸依替卡因
• 中文别名: 依替卡因盐酸盐
• 英文名称: Etidocaine Hydrochloride
• 英文别名: N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide;hydrochloride
• CAS: 36637-19-1
• 化学式: C17H29ClN2O
• 分子量: 312.9
• InChiKey: LMWQQUMMGGIGJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.66
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  33.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• PRODRUG COMPOSITIONS, PRODRUG NANOPARTICLES, AND METHODS OF USE THEREOF
  申请人：Washington University

  公开号：US20160279060A1

  公开（公告）日：2016-09-29

  The present invention encompasses prodrug compositions, nanoparticles comprising one or more prodrugs, and methods of use thereof.

  本发明涵盖了前药组合物、包含一种或多种前药的纳米粒子，以及其使用方法。
• TERPENE COUPLING CONJUGATE
  申请人：LABORATOIRES ERIGER

  公开号：US20210361771A1

  公开（公告）日：2021-11-25

  The subject matter of the present invention relates to the use of an optionally branched linear terpene having at most one C═C unsaturation for the production of conjugates provided with self-assembly properties, as well as a self-assembly agent of formula (I): X(-Spacer-Y-Terpene) p (I) in which: “Terpene” is linear, optionally branched, having at most one C═C unsaturation; “Y” is a bond or a molecular fragment with a biodegradable bond; “Spacer” is a bond or a fragment comprising at least one carbon atom; “X” is a molecular fragment comprising at least one biodegradable bond; “p” ranges between 0.1 and 4; and the “-Spacer-Y-” group optionally can be a bond, as well as the conjugate resulting from the combination of the self-assembly agent of formula (I) with an active molecule MA.

  本发明的主题涉及使用最多具有一个C═C不饱和度的线性可选择分支的萜烯，用于具有自组装特性的共轭物的生产，以及具有以下式(I)的自组装剂： X(-Spacer-Y-Terpene) p (I) 其中： “萜烯”是线性的，可选择分支的，最多具有一个C═C不饱和度； “Y”是一个具有可生物降解键的键或分子片段； “Spacer”是一个包含至少一个碳原子的键或片段； “X”是一个包含至少一个可生物降解键的分子片段； “p”范围在0.1至4之间；以及 “-Spacer-Y-”基团可以选择是一个键， 以及由式(I)的自组装剂与活性分子MA的组合产生的共轭物。
• Hydrogel-containing medical articles and methods of using and making the same
  申请人：Faure Marie-Pierre

  公开号：US20050214376A1

  公开（公告）日：2005-09-29

  Medical articles including a hydrophilic water-swellable hydrogel and methods of using and making the articles are provided. The hydrogel may include a crosslinked mixture of a biocompatible polymer and a protein, such as polyethylene glycol and a soy protein. The hydrogel may further include an agent, such as diazolidinyl urea and iodopropynyl butylcarbamate, dispersed within the hydrophilic water-swellable hydrogel.

  提供了包括亲水性水膨胀性水凝胶的医疗文章以及使用和制作这些文章的方法。水凝胶可能包括生物相容性聚合物和蛋白质的交联混合物，例如聚乙二醇和大豆蛋白。水凝胶还可能在亲水性水膨胀性水凝胶中分散了一种药剂，如二嗪基脲和碘丙炔丁基氨基甲酸酯。
• Wound Dressings, Methods of Using the Same and Methods of Forming the Same
  申请人：Stasko Nathan

  公开号：US20120136323A1

  公开（公告）日：2012-05-31

  Provided according to some embodiments of the invention are wound dressings that include a polymer matrix and nitric oxide-releasing polysiloxane macromolecules within and/or on the polymer matrix. Also provided are wound dressing kits and methods of using and forming such wound dressings.

  根据本发明的某些实施例，提供了包括聚合物基质和硅氧烷聚合物中释放一氧化氮的大分子的敷料。还提供了创伤敷料套件和使用和形成这种创伤敷料的方法。
• Composite materials for controlled release of water soluble products
  申请人：Ying Y. Jackie

  公开号：US20060024377A1

  公开（公告）日：2006-02-02

  Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materials are designed so as to provide controlled release of the water soluble molecule.

  本发明涉及一种复合材料，包括吸附在碱性无机材料上的水溶性化合物和可生物降解聚合物，其产生酸性降解产物，描述了其制备方法和使用方法，其中复合材料的设计旨在提供水溶性分子的控制释放。