2-[4-(3-cyclopropylpyrazin-2-yl)phenyl]-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide | 1146395-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-(3-cyclopropylpyrazin-2-yl)phenyl]-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide
• 英文别名: 2-[4-(3-cyclopropylpyrazin-2-yl)phenyl]-N-[(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl]acetamide
• CAS: 1146395-54-1
• 化学式: C₂₄H₂₃F₃N₄O₂
• 分子量: 456.467
• InChiKey: FKXPYVUGTJYPHQ-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  [4-(3-cyclopropylpyrazin-2-yl)phenyl]acetic acid 、 (R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethylamine dihydrochloride 在 N-羟基-7-氮杂苯并三氮唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以73.8%的产率得到2-[4-(3-cyclopropylpyrazin-2-yl)phenyl]-N-{(1R)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide
  参考文献：
  名称：

  [EN] HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  [FR] ANTAGONISTES DE CANAUX CALCIQUES DE TYPE T À BASE DE PHÉNYLE AMIDE HÉTÉROCYCLIQUE

  摘要：

  本发明涉及杂环苯酰胺化合物，这些化合物是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及T型钙通道的疾病中使用这些化合物和组合物。

  公开号：

  WO2009054984A1

文献信息

• HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS
  申请人：Barrow James C.

  公开号：US20100261724A1

  公开（公告）日：2010-10-14

  The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环苯酰胺化合物，其为T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的使用。
• Heterocycle phenyl amide T-type calcium channel antagonists
  申请人：Barrow James C.

  公开号：US08637513B2

  公开（公告）日：2014-01-28

  The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环苯酰胺化合物，其为T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。本发明还涉及包含这些化合物的制药组合物及其在预防或治疗涉及T型钙通道的疾病中的使用。
• US8637513B2
  申请人：——

  公开号：US8637513B2

  公开（公告）日：2014-01-28
• [EN] HETEROCYCLE PHENYL AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS<br/>[FR] ANTAGONISTES DE CANAUX CALCIQUES DE TYPE T À BASE DE PHÉNYLE AMIDE HÉTÉROCYCLIQUE
  申请人：MERCK & CO INC

  公开号：WO2009054984A1

  公开（公告）日：2009-04-30

  The present invention is directed to heterocycle phenyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及杂环苯酰胺化合物，这些化合物是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及T型钙通道的疾病中使用这些化合物和组合物。