dysifragilones A 和 B 以及 dysidavarones 的简明合成首次以不同于常见中间体的方式完成。合成路线的特点是通过分子内还原 Heck 反应构建双甲双胍 A 和 B 的 6/5/6/6/-四环,以及分子内钯催化的空间位阻酮的 α-芳基化形成四环 [7.7.1.0 2 ,7 .0 10,15 ]达达瓦隆 C 的十七烷核心结构。后期引入氨基和乙氧基是有效的。
Total Synthesis of (±)-Clavilactones A, B, and Proposed D through Iron-Catalyzed Carbonylation-Peroxidation of Olefin
作者:Leiyang Lv、Baojian Shen、Zhiping Li
DOI:10.1002/anie.201400326
日期:2014.4.14
clavilactones A, B, and the previously proposedD have been synthesized through iron‐catalyzed carbonylation–peroxidation of a 1,5‐diene. Three steps from aldehydes, alkenes, and tert‐butylhydroperoxide build up α,β‐epoxy‐γ‐butyrolactone skeleton as a key building block for synthesis of clavilactone family and its derivatives. Based on our results, the structure of the proposed clavilactone D is not correct