N'-[(E)-(4-cyanophenyl)methylidene]-2-pyrazinecarbohydrazide | 1206198-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N'-[(E)-(4-cyanophenyl)methylidene]-2-pyrazinecarbohydrazide
• 英文别名: N-[(E)-(4-cyanophenyl)methylideneamino]pyrazine-2-carboxamide
• CAS: 1206198-60-8
• 化学式: C₁₃H₉N₅O
• 分子量: 251.247
• InChiKey: TXDYLGKWCFPWFV-CAOOACKPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡嗪-2-甲酰肼 、 4-氰基苯甲醛 以 乙醇 、 水 为溶剂， 以80%的产率得到N'-[(E)-(4-cyanophenyl)methylidene]-2-pyrazinecarbohydrazide
  参考文献：
  名称：

  Synthesis and antimycobacterial activity of N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives

  摘要：

  The present article describes a series of twenty-six N'-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide (4-29), which were synthesized and evaluated for their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG). Afterwards, the non-cytotoxic compounds (4, 6, 8, 15, 21, 23, 24, 27 and 28) were assessed against Mycobacterium tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA) and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. The compounds 6, 23, 27 and 28 exhibited a significant activity (50-100 mu g/mL) when compared with first line drugs such as pyrazinamide and were not cytotoxic in their respective MIC values. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.08.009

文献信息

• Synthesis and antimycobacterial activity of N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide derivatives
  作者：Fátima M.F. Vergara、Camilo H. da S. Lima、Maria das Graças M. de O. Henriques、André L.P. Candéa、Maria C.S. Lourenço、Marcelle de L. Ferreira、Carlos R. Kaiser、Marcus V.N. de Souza

  DOI：10.1016/j.ejmech.2009.08.009

  日期：2009.12

  The present article describes a series of twenty-six N'-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide (4-29), which were synthesized and evaluated for their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG). Afterwards, the non-cytotoxic compounds (4, 6, 8, 15, 21, 23, 24, 27 and 28) were assessed against Mycobacterium tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA) and the activity expressed as the minimum inhibitory concentration (MIC) in mu g/mL. The compounds 6, 23, 27 and 28 exhibited a significant activity (50-100 mu g/mL) when compared with first line drugs such as pyrazinamide and were not cytotoxic in their respective MIC values. (C) 2009 Elsevier Masson SAS. All rights reserved.