Methyl 6-amino-2-methylhexanoat | 17377-72-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Methyl 6-amino-2-methylhexanoat
• 英文别名: Methyl 6-amino-2-methylhexanoate
• CAS: 17377-72-9
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: WDPDNIDYRUBADG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• AMINO ACID DERIVATIVES AND ABSORABLE POLYMERS THEREFROM
  申请人：Bezwada Rao S.

  公开号：US20120208896A1

  公开（公告）日：2012-08-16

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及一种新类水解性氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚脲和由此制备的聚氨酯。所得的可吸收聚合物可用于药物输送、组织工程、组织粘合剂、粘附预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科器械、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控降解特性。
• POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF
  申请人：Kopecková Pavla

  公开号：US20130156722A1

  公开（公告）日：2013-06-20

  Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.

  本文描述了一种可生物降解的药物传递共轭物，用于有效地将生物活性物质传递给受试者。药物传递共轭物包括水溶性高分子量线性可生物降解聚合物骨架，该骨架包括通过第一（主链）可断裂连接剂相互连接的多个线性水溶性聚合物段，其中生物活性物质与至少一个水溶性聚合物段，至少一个可断裂连接剂或其组合共价键合。与先前的传递共轭物相比，这些共轭物具有许多优点。本文还描述了制备和使用这些共轭物的方法。
• AMINO ACID DERIVATIVES AND ABSORBABLE POLYMERS THEREFROM
  申请人：Bezwada Biomedical, LLC

  公开号：US20150065586A1

  公开（公告）日：2015-03-05

  The present invention relates to the discovery of new class of hydrolysable amino acid derivatives and absorbable polyester amides, polyamides, polyepoxides, polyureas and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, stents, stent coatings, highly porous foams, reticulated foams, wound care, cardiovascular applications, orthopedic devices, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers should have a controlled degradation profile.

  本发明涉及一种新型可水解氨基酸衍生物和可吸收聚酯酰胺、聚酰胺、聚环氧化物、聚氨酯和聚氨酯的发现。由此制备的可吸收聚合物可用于药物传递、组织工程、组织粘合剂、粘附预防、骨蜡配方、医疗器械涂层、支架、支架涂层、高度多孔泡沫、网状泡沫、伤口护理、心血管应用、骨科设备、表面改性剂和其他可植入医疗器械。此外，这些可吸收聚合物应具有受控的降解特性。
• DERIVATIVES OF XANTHONE COMPOUNDS
  申请人：Agency for Science, Technology and Research

  公开号：EP2753613B1

  公开（公告）日：2020-03-04
• UNIVERSAL HISTIDINE-TAG BINDING COMPOUNDS AND METHODS OF USE THEREOF AS FLUORESCENT PROBES AND SENSORS
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20200256857A1

  公开（公告）日：2020-08-13

  This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.