2-diphenylphosphinyl-2'-(methylthio)biphenyl | 402822-68-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-diphenylphosphinyl-2'-(methylthio)biphenyl
• 英文别名: 1-Diphenylphosphoryl-2-(2-methylsulfanylphenyl)benzene
• CAS: 402822-68-8
• 化学式: C₂₅H₂₁OPS
• 分子量: 400.481
• InChiKey: KXHNMLCWSDQABM-UHFFFAOYSA-N

物化性质

• 沸点：
  606.2±55.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-diphenylphosphinyl-2'-(methylthio)biphenyl 在 三氯硅烷 、 三乙胺 作用下， 以 甲苯 为溶剂， 以78%的产率得到2-diphenylphosphino-2'-(methylthio)biphenyl
  参考文献：
  名称：

  Synthesis of biphenyl-based phosphines by Suzuki coupling

  摘要：

  A series of phosphine oxides has been synthesised by the palladium-catalysed Suzuki coupling of arylboronic acids with OPPh2(o-C6H4Br). Oil reduction with trichlorosilane. functionalised. biphenyl-based phosphine ligands were obtained in good yields. Our preliminary results indicate these ligands to be effective for palladium-catalysed C-C coupling reactions including the formation of their own oxides. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01981-5
• 作为产物：
  描述：

  二苯基膦 在 palladium diacetate 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ potassium phosphate 、 双氧水 、 sodium acetate 、 三苯基膦 作用下， 以 1,4-二氧六环 、 甲醇 、 N,N-二甲基乙酰胺 为溶剂， 反应 121.0h， 生成 2-diphenylphosphinyl-2'-(methylthio)biphenyl
  参考文献：
  名称：

  Palladium-catalysed synthesis of biaryl phosphines

  摘要：

  Monodentate, biphenyl-type phosphines have emerged as a powerful class of ligands in homogeneous catalysis. Synthetic methods for these ligands are limited, however. We report that the palladium-catalysed Suzuki coupling of OPR2(o-C6H4X) (R=Ph, t-Bu; X=Br, I) with arylboronic acids affords a variety of biaryl phosphine oxides including those that contain heterocycles. The corresponding phosphines are readily obtained by treatment with HSiCl3. The methodology provides an easy entry to monodentate biaryl and heterobiaryl P<^>X (X=N, O, S) phosphines with diverse steric and electronic properties. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.03.058