(RS)-ethoxy-[3-(3-methoxy-phenylamino)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester | 854761-86-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (RS)-ethoxy-[3-(3-methoxy-phenylamino)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester
• 英文别名: ethyl 2-ethoxy-2-[3-(3-methoxyanilino)-2-oxopyridin-1-yl]acetate
• CAS: 854761-86-7
• 化学式: C₁₈H₂₂N₂O₅
• 分子量: 346.383
• InChiKey: ONHBNGQDSUGPSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (RS)-(3-amino-2-oxo-2H-pyridin-1-yl)-ethoxy-acetic acid ethyl ester 、 3-甲氧基苯硼酸 以to give (RS)-ethoxy-[3-(3-methoxy-phenylamino)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester的产率得到(RS)-ethoxy-[3-(3-methoxy-phenylamino)-2-oxo-2H-pyridin-1-yl]-acetic acid ethyl ester
  参考文献：
  名称：

  Heterocyclyl substituted 1-alkoxy acetic acid amides

  摘要：

  本发明涉及新型杂环取代的1-烷氧基乙酸衍生物，其化学式为（I），其中R1到R6和A如说明书和权利要求中所定义，以及其生理上可接受的盐。这些化合物抑制由第VIIa因子和组织因子诱导的凝血因子Xa，IXa和凝血酶的形成，可用作药物。

  公开号：

  US20050137168A1

文献信息

• N-(4-CARBAMIMIDOYL-BENZYL)-2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1706396A1

  公开（公告）日：2006-10-04
• BETA-AMINOACID-DERIVATIVES AS FACTOR Xa INHIBITORS
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1723164A1

  公开（公告）日：2006-11-22
• US7056932B2
  申请人：——

  公开号：US7056932B2

  公开（公告）日：2006-06-06
• [EN] N-(4-CARBAMIMIDOYL-BENZYL) -2-ALKOXY-2-HETEROCYCLYL ACETAMIDES AS INHIBITORS OF THE FORMATION OF COAGULATION FACTORS XA, IXA AND THROMBIN INDUCED BY FACTOR VIIA<br/>[FR] ACETAMIDES DE N-(4-CARBAMIMIDOYL-BENZYL) -2-ALKOXY-2-HETEROCYCLYLE UTILISES EN TANT QU'INHIBITEURS DE LA FORMATION DE FACTEURS DE COAGULATION XA, IXA ET THROMBINE INDUITS PAR LE FACTEUR VIIA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005058868A1

  公开（公告）日：2005-06-30

  The invention is concerned with novel heterocyclyl substituted mandelic acid derivatives of formula (I) wherein R1 to R6 and A are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor and can be used as medicaments.
• [EN] BETA-AMINOACID-DERIVATIVES AS FACTOR Xa INHIBITORS<br/>[FR] DERIVES BETA-AMINOACIDE EN TANT QU'INHIBITEURS DU FACTEUR XA
  申请人：AVENTIS PHARMA GMBH

  公开号：WO2005095440A1

  公开（公告）日：2005-10-13

  The present invention relates to compounds of the Formula (I), in which R°; R1; R2; R3; R4; R5; R6; Q; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.