2-(1-adamantyl)-N-{[1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl}acetamide | 918333-40-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 2-(1-adamantyl)-N-{[1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl}acetamide
• 英文别名: 2-(1-adamantyl)-N-[[(3R,4S)-1-(3,3-dimethylbutyl)-3-fluoropiperidin-4-yl]methyl]acetamide
• CAS: 918333-40-1
• 化学式: C₂₄H₄₁FN₂O
• 分子量: 392.601
• InChiKey: MAZKZTCKLXYOEW-KBAYWCCJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• 3-Fluoro-Piperidine T-Type Calcium Channel Antagonists
  申请人：Barrow James C.

  公开号：US20100222387A1

  公开（公告）日：2010-09-02

  The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

  本发明涉及3-氟哌啶化合物，其为T型钙通道的拮抗剂，并且在治疗或预防涉及T型钙通道的神经学和精神疾病和疾病方面具有用处。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病方面的用途。
• [EN] 3-FLUORO-PIPERIDINE T-TYPE CALCIUM CHANNEL ANTAGONISTS<br/>[FR] ANTAGONISTES DU CANAL CALCIQUE DE TYPE T 3-FLUORO-PIPERIDINE
  申请人：MERCK & CO INC

  公开号：WO2007002361A2

  公开（公告）日：2007-01-04

  [EN] The present invention is directed to 3-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.
  [FR] Ces composés 3-fluoro-pipéridine sont des antagonistes des canaux calciques de type T et servent au traitement ou à la prévention de troubles neurologiques ou psychiatriques en rapport avec des canaux calciques de type T. des compositions pharmaceutiques comprennent ces composés et on les utilise pour prévenir ou traiter de telles maladies.