1,2-diaza-cyclododecane-3,12-dione | 29043-45-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2-diaza-cyclododecane-3,12-dione
• 英文别名: 1,2-Diaza-cyclododecan-3,12-dion；1,2-Diazacyclododecane-3,12-dione
• CAS: 29043-45-6
• 化学式: C₁₀H₁₈N₂O₂
• 分子量: 198.265
• InChiKey: JHFBEAGBYKWGBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 碘 作用下， 生成 1,2-diaza-cyclododecane-3,12-dione
  参考文献：
  名称：

  Steller, Journal fur praktische Chemie (Leipzig 1954), 1900, vol. <2> 62, p. 222

  摘要：

  DOI：

文献信息

• Solubilization and Targeted Delivery of Drugs With Self-Assembling Amphiphilic Polymers
  申请人：Diwan Anil

  公开号：US20100260743A1

  公开（公告）日：2010-10-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds such as drugs, vitamins, dyes, and imaging agents. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties useful for the targeted delivery of drugs and imaging agents.

  提供的两性可降解共聚物包括具有羟基亲水骨架和作为疏水组分的脂肪族侧链的共聚物。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶于水的有机化合物，如药物、维生素、染料和成像剂。这些聚合物可选择性地具有反应性功能基团，提供与抗体、配体和其他靶向基团的结合点，有助于药物和成像剂的靶向传递。
• SELF ASSEMBLING AMPHIPHILIC POLYMERS AS ANTIVIRAL AGENTS
  申请人：Diwan Anil

  公开号：US20100008938A1

  公开（公告）日：2010-01-14

  There are provided amphiphilic biodegradable copolymers comprising a hydrophilic backbone with pendant aliphatic groups as the hydrophobic component. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors that are capable of solubilizing insoluble organic compounds and disrupting viral coat proteins. The polymers optionally feature reactive functional groups that provide attachment points for antibodies, ligands, and other targeting moieties which mediate adherence of the aggregate to a viral target.

  提供的两性亲水可生物降解共聚物包括具有侧链脂肪族基作为疏水成分的亲水性骨架。这些聚合物在水性环境中形成纳米级分子聚集体，具有疏水内部，能够溶解不溶性有机化合物并破坏病毒外壳蛋白。这些聚合物可选择性地具有反应性功能基团，提供抗体、配基和其他靶向基团的附着点，介导聚集体与病毒靶标的粘附。
• SELF-ASSEMBLING AMPHIPHILIC POLYMERS AS ANTI-CANCER AGENTS
  申请人：Diwan Anil R.

  公开号：US20100239659A1

  公开（公告）日：2010-09-23

  The invention provides amphiphilic biocompatible copolymers which have a hydrophilic backbone and pendant hydrophobic groups. The polymers form nanoscale molecular aggregates in aqueous environments, which have hydrophobic interiors within which anticancer drugs may be solubilized. The polymers optionally feature attached antibodies, receptor ligands, and other targeting moieties which mediate adherence of the drug-carrying aggregates to targeted cancer cells.

  本发明提供了一种两性亲水的生物相容性共聚物，其具有亲水性骨架和挂链疏水基团。这些聚合物在水性环境中形成纳米级分子聚集体，其中具有疏水性内部，可在其中溶解抗癌药物。这些聚合物可选地具有连接的抗体、受体配体和其他靶向基团，这些基团介导药物携带聚集体与靶向癌细胞的附着。
• CARBOXYL RESIN, HARDENING COMPOSITION CONTAINING CARBOXYL RESIN, AND HARDENED MATERIAL THEREOF
  申请人：Ikegami Koichi

  公开号：US20110082229A1

  公开（公告）日：2011-04-07

  A carboxyl resin according to the present invention is obtained by a process including following steps: epoxy groups on a resin (a) having two or more epoxy groups in one molecule is made to react with 0.3-0.85 mol of a monocarboxylic acid (b) per one epoxy-group equivalent weight to obtain a reaction product (c); the epoxy group or groups on the reaction product (c) are made to react with 0.15-0.95 mol of a polybasic acid (d) per one epoxy-group equivalent weight to obtain a reaction product (e); and the epoxy group or groups on the reaction product (e) are further made to react with 1.0-5.0 mol of a monocarboxylic acid (f) per one epoxy-group equivalent weight. The carboxyl resin thus obtained has an acid value within a range from 20 to 200 mgKOH/g and is soluble in an organic solvent.

  根据本发明，通过以下步骤获得一种羧基树脂：将具有一个分子中两个或更多环氧基团的树脂（a）上的环氧基团与0.3-0.85摩尔的单羧酸（b）反应，以获得反应产物（c）；将反应产物（c）上的环氧基团与0.15-0.95摩尔的多元酸（d）反应，以获得反应产物（e）；将反应产物（e）上的环氧基团与1.0-5.0摩尔的单羧酸（f）进一步反应。因此获得的羧基树脂酸值在20至200mgKOH/g范围内，并且可溶于有机溶剂。
• Curable composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0039230A2

  公开（公告）日：1981-11-04

  Acurable resin composition comprising an epoxy resin, a hardener and an epoxy compound-dialkyl-amine adduct as a latent hardener. The composition has good storage stability at ambient temperatures and is rapidly heat-curable, and is usable as or in adhesives, paints, molding materials, and casting materials.

  由环氧树脂、固化剂和作为潜在固化剂的环氧化合物-二烷基-胺加合物组成的可固化树脂组合物。该组合物在环境温度下具有良好的储存稳定性，并能快速热固化，可用作粘合剂、涂料、成型材料和铸造材料。