cesium pentafluoroethanolate | 13994-46-2

• 分子结构分类: 有机化合物 - 有机卤素化合物
• 英文名称: cesium pentafluoroethanolate
• CAS: 13994-46-2
• 化学式: C₂F₅O*Cs
• 分子量: 267.919
• InChiKey: AUAHUDIVVRHXMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.49
• 重原子数：
  9.0
• 可旋转键数：
  0.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.06
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  cesium pentafluoroethanolate 、 2-溴苯乙酮 以 乙二醇二甲醚 为溶剂， 反应 24.0h， 以2.99 g的产率得到phenyl(pentafluoroethyloxymethyl)ketone
  参考文献：
  名称：

  Efficient synthesis of 5′-fluoroalkoxythiazoles via α-bromo-α-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides

  摘要：

  Novel alpha-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. alpha-Bromination yielded alpha-bromo-alpha-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5'-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.01.005
• 作为产物：
  描述：

  三氟乙酰氟 在 cesium fluoride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 4.0h， 生成 cesium pentafluoroethanolate
  参考文献：
  名称：

  Efficient synthesis of 5′-fluoroalkoxythiazoles via α-bromo-α-fluoroalkoxyacetophenones Hantzsch type cyclization with thioureas or thioamides

  摘要：

  Novel alpha-fluoroalkoxyacetophenones were synthesized by addition of the readily available 2,2-dimethoxy-2-phenylethanol to fluoroolefins. alpha-Bromination yielded alpha-bromo-alpha-fluoroalkoxyacetophenones, which on treatment with thioureas or thioamides gave thiazoles with fluoroalkoxy groups at the 5'-position by the Hantzsch-type cyclization. This provides a versatile methodology for the construction of heterocycles from aliphatic fluoroalkoxy containing building blocks. (C) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2012.01.005

文献信息

• Alternative synthetic routes to hydrofluoroolefins
  作者：Yu. L. Yagupolskii、N.V. Pavlenko、S.V. Shelyazhenko、A.A. Filatov、M.M. Kremlev、A.I. Mushta、I.I. Gerus、Sheng Peng、V.A. Petrov、Mario Nappa

  DOI：10.1016/j.jfluchem.2015.08.001

  日期：2015.11

  A series of hydrofluoroolefins with -CF=CH2, -CH=CHF and -CH=CF2 groups were designed and prepared via various synthetic routes, including HX or BrF elimination, Wittig-type olefination or fluorination using SF4. (C) 2015 Elsevier B.V. All rights reserved.