benzyl-(3-methyl-benzyliden)-amine | 929109-60-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl-(3-methyl-benzyliden)-amine
• 英文别名: m-Toluylaldehyd-benzylimin
• CAS: 929109-60-4
• 化学式: C₁₅H₁₅N
• 分子量: 209.291
• InChiKey: ZTQVNXHQULARIG-FOWTUZBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.61
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  benzyl-(3-methyl-benzyliden)-amine 、 sodium ethanolate 生成 benzylidene-(3-methyl-benzyl)-amine
  参考文献：
  名称：

  88.对称黑社会质子系统。第八部分。对称三单元组的系统和芳族侧链的反应性，和的效应之间的类比米3'-取代上移动性和平衡在α γ -diphenylmethyleneazomethine系统

  摘要：

  DOI：

  10.1039/jr9320000696
• 作为产物：
  描述：

  3-甲基苯甲醛 、 苄胺 在 3 A molecular sieve 作用下， 以 苯 为溶剂， 生成 benzyl-(3-methyl-benzyliden)-amine
  参考文献：
  名称：

  铜催化多组分级联法合成六氢-1 H-异吲哚酮

  摘要：

  铜催化的亚胺，二烯基锡烷和丙烯酰氯的偶联，然后进行狄尔斯-阿尔德反应，得到六氢-1 H-异吲哚酮。通过Pd催化的交叉偶联使核心多样化，从而为异吲哚酮组合文库定义了一种新的模块化方法。

  DOI：

  10.1021/jo0621773

文献信息

• Grammaticakis, Bulletin de la Societe Chimique de France, 1941, vol. <5> 8, p. 38,49
  作者：Grammaticakis

  DOI：——

  日期：——
• Steric and electronic effects on the regioselective formation of platinum(II) metallacycles: crystal structure of [PtMe(3-MeC6H3CHNCH2C6H5)(PPh3)]
  作者：Margarita Crespo、Xavier Solans、Mercè Font-Bardía

  DOI：10.1016/0022-328x(96)83109-3

  日期：1996.2

  The reaction of [Pt(2)Me(4)(mu-SMe(2))(2)] (1) with imines 3,4-(OMe)(2)C6H3CH=NCH(2)Ph (2c) and 3-MeC(6)H(6)CH=NCH(2)Ph (2e) yields cyclometallated compounds [PtMe(3,4-(OMe)(2)C6H2CH=NCH(2)Ph)(SMe(2))] (4c) and [PtMe(3-MeC(6)H(3)CH=NCH(2)Ph)(SMe(2))] (4e) arising from selective metallation at the less hindered of the two non-equivalent ortho positions of the aryl ring, followed by loss of methane. These compounds react with PPh(3) to give cyclometallated compounds [PtMe(3,4-(OMe)(2)C6H2CH=NCH(2)Ph)(PPh(3))] (5c) and [PtMe(3-MeC(6)H(3)CH=NC(2)Ph)(PPh(3))] (5e). Imines 2,4,6-(OMe)(3)C6H2CH=NCH(2)Ph (2a), 3,5-(OMe)(2)C6H3CH=NCH(2)Ph (2b) and 2,5-Me(2)C(6)H(3)CH=NCH(2)Ph (2d) coordinate to platinum through the nitrogen atom to yield compounds [PtMe(2)(ArCH=NCH(2)Ph)(SMe(2))] (3) but fail to produce cyclometallated compounds.
• A Novel Approach for Mannich-Type Bases Having a Terminal Olefin:  Zinc Triflate and Water-Promoted Cyclization/C−N Bond Cleavage Process
  作者：Kaori Ishimaru、Takakazu Kojima

  DOI：10.1021/jo0011888

  日期：2000.12.1
• Reduction and reductive coupling of imines by Sm(II)-based reagents
  作者：Myeongseob Kim、Brian W Knettle、Anders Dahlén、Göran Hilmersson、Robert A Flowers

  DOI：10.1016/j.tet.2003.06.004

  日期：2003.12

  The reductive coupling of aldimines and ketimines by a series of Sm(II)-based reagents (SmI2, SmI2-HMPA, SmBr2, SmN[Si(CH3)(3)](2)}(2), and SmI2/triethylamine/water) were examined. In general, aldimines and ketimines were efficiently reduced or coupled using reductants that are more powerful than SmI2, and the use of SmN[Si(CH3)(3)](2)}(2) led to higher diastereoselectivities in reductive coupling reactions. Surprisingly, only the combination of SMI2/triethylamine/water was capable of reducing and coupling para-substituted benzaldimines and coupling ketimines. (C) 2003 Elsevier Ltd. All rights reserved.